Human liver contains isoforms of dihydrodiol dehydrogenase (DD1, DD2, DD3 and DD4), which belong to the aldo-oxo reductase/aldo-keto reductase (AKR) superfamily, have 20α- or 3α-hydroxysteroid dehydrogenase (HSD) activity. DD1 is also designated AKR1C1, DDH or DDH1 while DD2 also can be designated AKR1C2, dDD, BABP or DDH2. AKR1C3 and 3α-HSD are alternate designations for DD3, while DD4 also can be called AKR1C4, CD or CHDR. DD1 and DD2 are 20α-HSDs, whereas DD3 and DD4 are the 3α-HSDs. The multiple human cytosolic dihydrodiol dehydrogenases are involved in the metabolism of xenobiotics, such as polycyclic aromatic hydrocarbons, pesticides and steroid hormones, and are responsible for the reduction of ketone-containing drugs by using NADH or NADPH as a cofactor. The 20α-HSD catalyzes the reaction of progesterone to the inactive form 20α-hydroxyprogesterone. The 3α-HSD is a cytosolic, monomeric, NADPH-dependent oxidoreductase that reduces 3-keto-5-dihydrosteroids to their tetrahydro products. DD1 and DD2 are ubiquitously expressed, whereas DD4 mRNA is restricted to the liver. DD3 is a unique enzyme that can specifically catalyze the dehydrogenation of trans-benzenedihydrodiol and trans-naphthalenedihydrodiol.
Alexa Fluor® est une marque déposée de Molecular Probes Inc., OR., USA
LI-COR® et Odyssey® sont marques déposées de LI-COR Biosciences
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps DD3 (D-9) | sc-398596 | 200 µg/ml | $316.00 | |||
DD3 (D-9): m-IgG Fc BP-HRP Kit | sc-538476 | 200 µg Ab; 10 µg BP | $354.00 | |||
DD3 (D-9): m-IgGκ BP-HRP Kit | sc-536098 | 200 µg Ab; 40 µg BP | $354.00 | |||
DD3 (D-9): m-IgG1 BP-HRP Kit | sc-545720 | 200 µg Ab; 20 µg BP | $354.00 | |||
DD3 (D-9) peptide neutralisant | sc-398596 P | 100 µg/0.5 ml | $68.00 |