DBH Antibody (A-9): sc-365710
- DBH Antibody (A-9) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 391-603 mapping near the C-terminus of DBH of human origin
- DBH Antibody (A-9) is recommended for detection of DBH of human origin by WB, IP, IF and ELISA
- Anti-DBH Antibody (A-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for DBH Antibody (A-9) for WB applications. These reagents are now offered in bundles with DBH Antibody (A-9) (see ordering information below).
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SEE ALSO...
DBH Antibody (A-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects dopamine beta-hydroxylase (DBH) of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-DBH antibody (A-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Dopamine beta-hydroxylase plays a crucial role in the biosynthesis of catecholamines by catalyzing the conversion of dopamine to noradrenaline, which is essential for proper functioning of the sympathetic nervous system and regulation of blood pressure and heart rate. DBH (A-9) monoclonal antibody specifically detects expression in noradrenergic and adrenergic neurons, as well as in neuroendocrine cells, making DBH a specific marker for noradrenergic processes. The active form of DBH is a homotetramer, localized within the lumen of synaptic vesicles in nerve cells, where DBH associates with both the membrane and cytosol. DBH expression is influenced by nerve growth factor and insulin growth factor-1, and regulated by intracellular second messengers such as protein kinase A, cyclic AMP, diacylglycerol, and calcium ions. Transcriptional regulation of DBH is mediated by transcription factors including Sp1, CREB, and AP-1 proteins, which encompass c-Fos, c-Jun, and JunD, highlighting the complex regulatory mechanisms that govern DBH expression and activity.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DBH Antibody (A-9) | sc-365710 | 200 µg/ml | $322.00 | |||
DBH Antibody (A-9): m-IgG Fc BP-HRP Bundle | sc-527394 | 200 µg Ab; 10 µg BP | $361.00 | |||
DBH Antibody (A-9): m-IgG1 BP-HRP Bundle | sc-532767 | 200 µg Ab; 20 µg BP | $361.00 | |||
DBH Antibody (A-9) AC | sc-365710 AC | 500 µg/ml, 25% agarose | $424.00 | |||
DBH Antibody (A-9) HRP | sc-365710 HRP | 200 µg/ml | $322.00 | |||
DBH Antibody (A-9) FITC | sc-365710 FITC | 200 µg/ml | $336.00 | |||
DBH Antibody (A-9) PE | sc-365710 PE | 200 µg/ml | $349.00 | |||
DBH Antibody (A-9) Alexa Fluor® 488 | sc-365710 AF488 | 200 µg/ml | $364.00 | |||
DBH Antibody (A-9) Alexa Fluor® 546 | sc-365710 AF546 | 200 µg/ml | $364.00 | |||
DBH Antibody (A-9) Alexa Fluor® 594 | sc-365710 AF594 | 200 µg/ml | $364.00 | |||
DBH Antibody (A-9) Alexa Fluor® 647 | sc-365710 AF647 | 200 µg/ml | $364.00 | |||
DBH Antibody (A-9) Alexa Fluor® 680 | sc-365710 AF680 | 200 µg/ml | $364.00 | |||
DBH Antibody (A-9) Alexa Fluor® 790 | sc-365710 AF790 | 200 µg/ml | $364.00 |