Date published: 2025-9-9

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Anticorps DAT/Dopamine Transporter/SLC6A3 (hDAT-LOOP): sc-58517

4.7(3)
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Fiches techniques
  • L'anticorps DAT/Dopamine Transporter/SLC6A3 hDAT-LOOP est un monoclonal IgG2a de rat fourni en 200 µg/ml
  • soulevée contre les acides aminés 180-218 correspondant à la deuxième boucle extracellulaire de DAT d'origine human.
  • recommandé pour la détection de DAT d'origine mouse, rat et human par WB, IP, IF et IHC(P)
  • Voir DAT/Dopamine Transporter/SLC6A3 (6-8D6): sc-32259 pour d'autres anticorps conjugués DAT/Dopamine Transporter/SLC6A3, dont AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 et 790.
  • Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire DAT/Dopamine Transporter/SLC6A3 (hDAT-LOOP). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.

    ACCÈS RAPIDE AUX LIENS

    VOIR ÉGALEMENT...

    The members of the G protein-coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory, depending on the type of receptor to which it binds. β-adrenergic receptor bound to adrenaline activates adenylyl cyclase, while α2-adrenergic receptor bound to adrenaline inhibits adenylyl cyclase. The dopamine receptors are divided into two classes, D1 and D2, which differ in their functional characteristics in that D1 receptors stimulate adenylyl cyclase, while D2 receptors inhibit adenylyl cyclase activity. Five different subtypes of dopamine receptor have been described to date. D1DR and D5DR belong to the D1 subclass, while D2DR, D3DR and D4DR belong to the D2 subclass of dopamine receptors. The dopamine transporter, DAT, is a sodium and chloride-dependent dopamine transporter. DAT also can transport dopamine neurotoxins and has been implicated in the selective vulnerability of nigrostriatal dopaminergic neurons in major models of Parkinson's disease.

    Pour la Recherche Uniquement. Non destiné à un usage diagnostique ou thérapeutique.

    Informations pour la commande

    Nom du produitRef. CatalogueCOND.Prix HTQTÉFavoris

    Anticorps DAT/Dopamine Transporter/SLC6A3 (hDAT-LOOP)

    sc-58517
    200 µg/ml
    $316.00

    I am using DAT (hDAT-LOOP): sc-58517 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

    Posée par: Germaine
    We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
    Répondue par: Technical Support
    Date de publication: 2017-02-24
    • y_2025, m_9, d_8, h_8CST
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    Rated 5 de 5 de par Really nice IHC staining!Great antibody for IHC on paraffin sections and WB. Specific and reliable, it's a smart choice for DAT detection.
    Date de publication: 2017-01-27
    Rated 4 de 5 de par Produced clear immunoperoxidase cytoplasmicProduced clear immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human hippocampus tissue. -SCBT QC
    Date de publication: 2015-06-26
    Rated 5 de 5 de par Great antibody for WesternGreat antibody for Western, strong band detected in SK-N-SH whole cell lysate. -SCBT QC
    Date de publication: 2015-01-25
    • y_2025, m_9, d_8, h_8
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    Anticorps DAT/Dopamine Transporter/SLC6A3 (hDAT-LOOP) est évalué 4.7 de 5 de 3.
    • y_2025, m_9, d_8, h_8
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