Anticorps DAP-3 (E-9): sc-398441
- L'Anticorps DAP-3 (E-9) est un monoclonal de souris IgG2b (chaîne légère kappa) fourni en 200 µg/ml
- dirigé contre les acides aminés 149-318 dans une région interne de DAP-3 d'origine human
- recommandé pour la détection de DAP-3 d'origine human par WB, IP, IF et ELISA
- 2b BP-HRP">m-IgG2b BP-HRP et m-IgGκ BP-HRP sont les réactifs de détection secondaire préférés pour l'anticorps DAP-3 (E-9) pour les applications WB. Ces réactifs sont désormais proposés en lots avec l'anticorps DAP-3 (E-9)(voir les informations relatives à la commande ci-dessous).
The death-associated protein 3 (DAP-3), is a nucleotide-binding protein that contains a potential P-loop motif. It is a positive mediator of programmed cell death; overexpressed intact full-length protein is required in order to induce apoptosis. DAP-3 functions downstream of its receptor signaling complex and its death promoting effects depend on caspase activity. It also interacts with the glucocorticoid receptor (GR), where its main interaction domain is the amino-terminal region, which acts in a dominant-negative fashion to protect cells from apoptosis. DAP-3 protein may also play a role in modulating the cytoplasmic GR/HSP 90 complex. It is conserved at the functional, as well as the structural level, and is ubiquitously expressed in highly proliferative epithelial compartments of various tissues. Unlike a number of other proteins, DAP-3 retains its mitochondrial localization during the induction of apoptosis.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps DAP-3 (E-9) | sc-398441 | 200 µg/ml | $316.00 | |||
DAP-3 (E-9): m-IgGκ BP-HRP Kit | sc-536058 | 200 µg Ab; 40 µg BP | $354.00 | |||
DAP-3 (E-9): m-IgG2b BP-HRP Kit | sc-549507 | 200 µg Ab; 10 µg BP | $354.00 |