Cytokeratin 7 Antibody (LP5K): sc-53264

Cytokeratin 7 Antibody (LP5K) is a mouse monoclonal IgG2b kappa light chain antibody engineered to detect Cytokeratin 7, also known as KRT7 or sarcolectin. Cytokeratin 7 monoclonal antibody (LP5K) is raised against cytoskeletal proteins from cultured HeLa cells of human origin, and is suitable for various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Cytokeratin 7 is an intermediate filament protein integral to the structural framework of epithelial cells, providing essential mechanical support and maintaining cellular integrity. Cytokeratin 7 (LP5K) antibody recognizes proteins that undergo significant post-translational modifications, such as phosphorylation, which are critical for regulating filament assembly, dynamics, and interactions with other cellular proteins. These modifications play a vital role in cellular processes like differentiation, migration, and response to stress, thereby influencing tissue organization and function. Anti-Cytokeratin 7 antibody (LP5K) helps researchers effectively investigate epithelial cell biology, monitor differentiation pathways, and identify malignant transformations in various cancers. Cytokeratin 7 serves as a valuable biomarker for distinguishing between different tumor types, aiding in accurate diagnosis and classification. Cytokeratin 7 (LP5K) monoclonal antibody enables advanced research and reliable diagnostic applications in cell biology, pathology, and oncology.

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Cytokeratin 7 Antibody (LP5K) References:

1. Immunohistochemical detection of uroplakin III, cytokeratin 7, and cytokeratin 20 in canine urothelial tumors.  |  Ramos-Vara, JA., et al. 2003. Vet Pathol. 40: 55-62. PMID: 12627713
2. Cytokeratin 7 and cytokeratin 20 expression in colorectal adenocarcinomas.  |  Bayrak, R., et al. 2011. Pathol Res Pract. 207: 156-60. PMID: 21282015
3. An immunohistochemical comparison of cytokeratin 7, cytokeratin 15, cytokeratin 19, CAM 5.2, carcinoembryonic antigen, and nestin in differentiating porocarcinoma from squamous cell carcinoma.  |  Mahalingam, M., et al. 2012. Hum Pathol. 43: 1265-72. PMID: 22285043
4. p16ink4 and cytokeratin 7 immunostaining in predicting HSIL outcome for low-grade squamous intraepithelial lesions: a case series, literature review and commentary.  |  Huang, EC., et al. 2016. Mod Pathol. 29: 1501-1510. PMID: 27515495
5. FOXA1 promotes proliferation, migration and invasion by transcriptional activating KRT7 in human gastric cancer cells.  |  Liu, BL., et al. 2019. J Biol Regul Homeost Agents. 33: 1041-1050. PMID: 31317696
6. Identification of novel biomarkers, MUC5AC, MUC1, KRT7, GAPDH, CD44 for gastric cancer.  |  Yang, J. 2020. Med Oncol. 37: 34. PMID: 32219571
7. MicroRNA-216a targets WT1 expression and regulates KRT7 transcription to mediate the progression of pancreatic cancer-A transcriptome analysis.  |  Wang, W., et al. 2021. IUBMB Life. 73: 866-882. PMID: 33759343
8. Prognostic relevance and putative histogenetic role of cytokeratin 7 and MUC5AC expression in Crohn's disease-associated small bowel carcinoma.  |  Arpa, G., et al. 2021. Virchows Arch. 479: 667-678. PMID: 33963925
9. Cytokeratin 7 and 19 expression in oropharyngeal and oral squamous cell carcinoma.  |  Woods, RSR., et al. 2022. Eur Arch Otorhinolaryngol. 279: 1435-1443. PMID: 34046748
10. The major binding protein of the interferon antagonist sarcolectin in human placenta is a macrophage migration inhibitory factor.  |  Zeng, FY., et al. 1993. Arch Biochem Biophys. 303: 74-80. PMID: 7683862

The preferred Cytokeratin 7 antibody is Cytokeratin 7 Antibody (RCK105): sc-23876.