Cytokeratin 5/6/18 Antibody (0.N.345): sc-70925

Cytokeratin 5/6/18 Antibody (0.N.345) is a mouse monoclonal IgG1 kappa light chain antibody that detects Cytokeratin 5/6/18 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Cytokeratin 5/6/18 antibody (0.N.345) is available as a non-conjugated format. Cytokeratins are intermediate filament proteins expressed in pairs within keratinized and non-keratinized epithelial tissues, maintaining structural integrity and function of epithelial cells. Cytokeratin 5/6/18 (0.N.345) plays a crucial role in epithelial cell differentiation and serves as a marker for tissue specialization, essential for understanding pathological conditions including malignant tumors. Cytokeratin 5 appears in normal basal cells, while Cytokeratin 6 expresses in suprabasal keratinocytes during wound healing, and Cytokeratin 18 forms a key component of simple epithelia and adenocarcinomas. Mutations in the KRT5 gene can lead to epidermolysis bullosa, highlighting Cytokeratin 5/6/18′s significance in normal physiology and disease states. Anti-Cytokeratin 5/6/18 antibody (0.N.345) effectively detects these proteins across multiple applications, making this reagent invaluable for epithelial biology and disease research.

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Cytokeratin 5/6/18 Antibody (0.N.345) References:

1. An analysis of cyclin D1, cytokeratin 5/6 and cytokeratin 8/18 expression in breast papillomas and papillary carcinomas.  |  Wang, Y., et al. 2013. Diagn Pathol. 8: 8. PMID: 23327593
2. Role of p40 and cytokeratin 5/6 in the differential diagnosis of sinonasal undifferentiated carcinoma.  |  Singh, L., et al. 2014. Ann Diagn Pathol. 18: 261-5. PMID: 25017972
3. The Value of Cytokeratin 5/6, p63 and Thyroid Transcription Factor-1 in Adenocarcinoma, Squamous Cell Carcinoma and Non-Small-Cell Lung Cancer of the Lung.  |  Argon, A., et al. 2015. Turk Patoloji Derg. 31: 81-8. PMID: 25944390
4. Immunohistochemical co-expression status of cytokeratin 5/6, androgen receptor, and p53 as prognostic factors of adjuvant chemotherapy for triple negative breast cancer.  |  Maeda, T., et al. 2016. Med Mol Morphol. 49: 11-21. PMID: 26009308
5. The application of cytokeratin-18 as a biomarker for drug-induced liver injury.  |  Korver, S., et al. 2021. Arch Toxicol. 95: 3435-3448. PMID: 34322741
6. Utility of GATA-3 and Cytokeratin 5/6 Immunostains in Separating Condyloma Acuminatum Arising in the Urinary Tract From Non-Invasive Papillary Urothelial Carcinoma.  |  Montoya-Cerrillo, D., et al. 2022. Int J Surg Pathol. 30: 260-264. PMID: 34665053
7. Clinicopathological features of cytokeratin 5-positive pulmonary adenocarcinoma.  |  Terada, K., et al. 2023. Histopathology. 82: 439-453. PMID: 36239561
8. Plasma Cytokeratin-18 Fragment Level Reflects the Metabolic Phenotype in Obesity.  |  Goralska, J., et al. 2023. Biomolecules. 13: PMID: 37189422
9. Visceral Obesity and Cytokeratin-18 Antigens as Early Biomarkers of Liver Damage.  |  de Alteriis, G., et al. 2023. Int J Mol Sci. 24: PMID: 37446065
10. Prognostic Value Of Basal Markers (Epidermal Growth Factor Receptor 'EGFR' And Cytokeratin 5/6) Expression In Triple-Negative Invasive Breast Cancer.  |  ElFeky, AW., et al. 2023. J Pak Med Assoc. 73(Suppl 4): S161-S166. PMID: 37482851

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cytokeratin 5/6/18 Antibody (0.N.345) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Cytokeratin 5/6/18 Antibody (0.N.345) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cytokeratin 5/6/18 Antibody (0.N.345) Specifications

Alternate Product Name: KRT5, KRT6, KRT18

Product Clone Name: 0.N.345

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Cytokeratin 5/6/18

Epitope Species: human

Product Reactivity/Detection: Cytokeratin 5, Cytokeratin 6 and Cytokeratin 18

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Cytokeratin 5/6/18 Antibody (0.N.345): N/A

The preferred Cytokeratin 18 antibody is Cytokeratin 18 Antibody (RGE53): sc-32329.