Cytokeratin 4 Antibody (5F132): sc-70919

Cytokeratin 4 Antibody (5F132) is a mouse monoclonal IgG1 antibody that detects Cytokeratin 4 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Cytokeratin 4 plays a crucial role in maintaining the structural integrity of epithelial cells, particularly in the differentiated layers of mucosal and esophageal epithelia, where Cytokeratin 4 contributes to the mechanical resilience and barrier function of these tissues. Cytokeratin 4 is part of the cytokeratin family, which consists of intermediate filament proteins that provide support and shape to epithelial cells. The expression of Cytokeratin 4 is particularly important as Cytokeratin 4 serves as a marker for epithelial differentiation and can aid in the diagnosis of various epithelial malignancies. By understanding the specific expression patterns of Cytokeratin 4, researchers can gain insights into the maturation and differentiation processes of epithelial tissues, making anti-Cytokeratin 4 antibody (5F132) a valuable tool in both basic research and clinical diagnostics. Cytokeratin 4 (5F132) antibody is essential for studies focused on epithelial biology and pathology, providing reliable detection and characterization of this important protein.

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Cytokeratin 4 Antibody (5F132) References:

1. Subchromosomal localization of two human cytokeratin genes (KRT4 and KRT15) by in situ hybridization.  |  Barletta, C., et al. 1990. Cytogenet Cell Genet. 54: 148-50. PMID: 1702379
2. Reduced expression of cytokeratin 4 and 13 is a valuable marker for histologic grading of esophageal squamous intraepithelial neoplasia.  |  Takashima, M., et al. 2012. J Med Dent Sci. 59: 17-28. PMID: 23896961
3. Molecular characterization and expression of the stratification-related cytokeratins 4 and 15.  |  Leube, RE., et al. 1988. J Cell Biol. 106: 1249-61. PMID: 2452170
4. Immunohistochemical markers of human sebaceous gland differentiation.  |  Latham, JA., et al. 1989. J Histochem Cytochem. 37: 729-34. PMID: 2467930
5. Latent transforming growth factor-β binding proteins (LTBP-1 and LTBP-2) and gingiva keratinization.  |  Chiang, MS., et al. 2015. Oral Dis. 21: 762-9. PMID: 25858550
6. Conjunctiva reconstruction by induced differentiation of human amniotic epithelial cells.  |  Yang, SP., et al. 2015. Genet Mol Res. 14: 13823-34. PMID: 26535697
7. Artificial Polymeric Scaffolds as Extracellular Matrix Substitutes for Autologous Conjunctival Goblet Cell Expansion.  |  He, M., et al. 2016. Invest Ophthalmol Vis Sci. 57: 6134-6146. PMID: 27832279
8. The effects of 3% diquafosol sodium eye drop application on meibomian gland and ocular surface alterations in the Cu, Zn-superoxide dismutase-1 (Sod1) knockout mice.  |  Ikeda, K., et al. 2018. Graefes Arch Clin Exp Ophthalmol. 256: 739-750. PMID: 29484560
9. CD24 and CK4 are upregulated by SIM2, and are predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer.  |  Takashima, K., et al. 2020. Int J Oncol. 56: 835-847. PMID: 32124945
10. Novel immortalized human vocal fold epithelial cell line: In vitro tool for mucosal biology.  |  Chen, X., et al. 2021. FASEB J. 35: e21243. PMID: 33428261

The preferred Cytokeratin 4 antibody is Cytokeratin 4 Antibody (6B10): sc-52321.