Coronin 2A Antibody (H-2): sc-376194

Coronin 2A Antibody (H-2) is a mouse monoclonal IgM antibody that detects Coronin 2A of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Coronin 2A (H-2) antibody is available as a non-conjugated format. Coronin 2A, also known as CLIPINB or WDR2, plays a crucial role in regulating actin dynamics and cellular processes such as motility and cytoskeletal rearrangement. Coronin 2A is primarily located in the cytoplasm and serves as a key component of the nuclear receptor corepressor complex, which is essential for recruiting histone deacetylases to form repressive chromatin structures. Coronin 2A′s ability to interact with various proteins within this complex underscores its importance in gene regulation and cellular signaling pathways. Additionally, Coronin 2A has been implicated in modulating intracellular membrane trafficking and organization, further highlighting its significance in maintaining cellular homeostasis. With diverse functional roles, Coronin 2A is vital for understanding cellular dynamics and the underlying mechanisms of various biological processes.

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Coronin 2A Antibody (H-2) References:

1. Coronin localizes to leading edges and is involved in cell spreading and lamellipodium extension in vertebrate cells.  |  Mishima, M. and Nishida, E. 1999. J Cell Sci. 112 (Pt 17): 2833-42. PMID: 10444378
2. Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus.  |  Spoerl, Z., et al. 2002. J Biol Chem. 277: 48858-67. PMID: 12377779
3. Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1.  |  Yoon, HG., et al. 2003. EMBO J. 22: 1336-46. PMID: 12628926
4. Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi apparatus.  |  Rybakin, V., et al. 2004. FEBS Lett. 573: 161-7. PMID: 15327992
5. Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules.  |  Gatfield, J., et al. 2005. Mol Biol Cell. 16: 2786-98. PMID: 15800061
6. Coronin 3 and its role in murine brain morphogenesis.  |  Hasse, A., et al. 2005. Eur J Neurosci. 21: 1155-68. PMID: 15813925
7. Coronin-1 function is required for phagosome formation.  |  Yan, M., et al. 2005. Mol Biol Cell. 16: 3077-87. PMID: 15829569
8. Coronin proteins as multifunctional regulators of the cytoskeleton and membrane trafficking.  |  Rybakin, V. and Clemen, CS. 2005. Bioessays. 27: 625-32. PMID: 15892111
9. Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.  |  Cai, L., et al. 2005. J Biol Chem. 280: 31913-23. PMID: 16027158

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Coronin 2A Antibody (H-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Coronin 2A Antibody (H-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Coronin 2A Antibody (H-2) Specifications

Alternate Product Name: CORO2A

Product Clone Name: H-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 371-480

Epitope Target: Coronin 2A

Epitope Species: human

Product Reactivity/Detection: Coronin 2A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Coronin 2A Antibody (H-2): N/A