The structure and function of the Golgi apparatus is controlled by a number of multi-protein complexes that are involved in glycosylation reactions and vesicular transport. The conserved oligomeric Golgi (COG) complex consists of three subcomplexes, termed LDLC, SEC34 and GTT (Golgi transport complex), all of which contain proteins necessary for proper Golgi operation. COG7 (Conserved oligomeric Golgi complex component 7), also known as CDG2E, is a 770 amino acid peripheral membrane protein. One of several members of the COG complex, COG7 is necessary for normal golgi function, namely maintaining Golgi structure and mediating vesicle docking and fusion. Defects in the gene encoding COG7 are the cause of congenital disorder of glycosylation type 2E (CDG2E), an inherited defect in N-glycosylation that results in under-glycosylated serum proteins and is characterized by psychomotor retardation, hypotonia, coagulation disorders and immunodeficiency.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps COG7 (L-06) | sc-101279 | 100 µg/ml | $333.00 |