Cdc20 Antibody (AR12): sc-53398
- Cdc20 Antibody (AR12) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against urea-denatured His6 Cdc20 recombinant protein of human origin
- recommended for detection of Cdc20 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See Cdc20 (E-7): sc-13162 for Cdc20 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Cdc20 Antibody (AR12) for WB and IHC(P) applications. These reagents are now offered in bundles with Cdc20 Antibody (AR12) (see ordering information below).
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Cdc20 Antibody (AR12) is a mouse monoclonal IgG1 antibody that detects Cdc20 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Cdc20 is a crucial regulatory protein that plays a significant role in the cell cycle, particularly in the transition from the G2 phase to mitosis. Anti-Cdc20 antibody (AR12) functions as an activator of the anaphase-promoting complex/cyclosome (APC/C), which is essential for the degradation of cyclins and other proteins that inhibit the progression of the cell cycle. This degradation is vital for the proper timing of mitotic events, ensuring that cells divide accurately and maintain genomic stability. Dysregulation of Cdc20 can lead to various diseases, including cancer, highlighting its importance as a target for therapeutic intervention. Cdc20 monoclonal antibody (AR12) provides a reliable tool for researchers studying cell cycle dynamics and the molecular mechanisms underlying cell division.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cdc20 Antibody (AR12) References:
- Regulation of APC-Cdc20 by the spindle checkpoint. | Yu, H. 2002. Curr Opin Cell Biol. 14: 706-14. PMID: 12473343
- Cyclin A and Nek2A: APC/C-Cdc20 substrates invisible to the mitotic spindle checkpoint. | van Zon, W. and Wolthuis, RM. 2010. Biochem Soc Trans. 38: 72-7. PMID: 20074038
- CDC20 maintains tumor initiating cells. | Xie, Q., et al. 2015. Oncotarget. 6: 13241-54. PMID: 25938542
- Coupling of Cdc20 inhibition and activation by BubR1. | Hein, JB., et al. 2021. J Cell Biol. 220: PMID: 33819340
- p53 directly downregulates the expression of CDC20 to exert anti-tumor activity in mantle cell lymphoma. | Chen, Y., et al. 2023. Exp Hematol Oncol. 12: 28. PMID: 36882855
- Functional analysis of recurrent CDC20 promoter variants in human melanoma. | Godoy, PM., et al. 2023. Commun Biol. 6: 1216. PMID: 38030698
- Functional analysis of Cdc20 reveals a critical role of CRY box in mitotic checkpoint signaling. | Zhang, Y., et al. 2024. Commun Biol. 7: 164. PMID: 38337031
- Bioinformatics analysis and experimental validation reveal that CDC20 overexpression promotes bladder cancer progression and potential underlying mechanisms. | Liu, Y., et al. 2024. Genes Genomics. 46: 437-449. PMID: 38438666
- CDC20 Holds Novel Regulation Mechanism in RPA1 during Different Stages of DNA Damage to Induce Radio-Chemoresistance. | Gao, Y., et al. 2024. Int J Mol Sci. 25: PMID: 39125953
- The Mitotic Checkpoint Complex controls the association of Cdc20 regulatory protein with the ubiquitin ligase APC/C in mitosis. | Sitry-Shevah, D., et al. 2024. Proc Natl Acad Sci U S A. 121: e2413089121. PMID: 39231204
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cdc20 Antibody (AR12) | sc-53398 | 200 µg/ml | $322.00 | |||
Cdc20 Antibody (AR12): m-IgG Fc BP-HRP Bundle | sc-536954 | 200 µg Ab; 10 µg BP | $361.00 | |||
Cdc20 Antibody (AR12): m-IgGκ BP-HRP Bundle | sc-534131 | 200 µg Ab; 40 µg BP | $361.00 | |||
Cdc20 Antibody (AR12): m-IgG1 BP-HRP Bundle | sc-544920 | 200 µg Ab; 20 µg BP | $361.00 |