Cdc20 Antibody (41): sc-136024
- Cdc20 Antibody (41) is a mouse monoclonal IgG1, cited in 2 publications, provided at 50 µg/0.5 ml
- raised against amino acids 60-253 of Cdc20 of human origin
- recommended for detection of Cdc20 of human origin by WB, IP and IF
- See Cdc20 (E-7): sc-13162 for Cdc20 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Cdc20 Antibody (41). This work is in progress.
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Cdc20 Antibody (41) is a mouse monoclonal IgG1 antibody that detects CDC20 in human samples through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). CDC20 is a crucial regulatory protein that plays a significant role in the cell cycle, particularly in the transition from the G2 phase to mitosis. Anti-CDC20 antibody (41) functions as an activator of the anaphase-promoting complex/cyclosome (APC/C), which is essential for the degradation of specific proteins that regulate cell cycle progression. This degradation is vital for the proper timing of mitosis, ensuring that cells do not prematurely enter anaphase, which could lead to genomic instability and contribute to tumorigenesis. CDC20 is predominantly located in the cytoplasm during interphase and translocates to the nucleus as cells prepare for mitosis, highlighting its dynamic role in cell cycle regulation. CDC20 (41) monoclonal antibody is an invaluable tool for researchers studying cell cycle dynamics and the mechanisms underlying cell division, providing insights into potential therapeutic targets for cancer treatment.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cdc20 Antibody (41) References:
- CDC20 regulates cardiac hypertrophy via targeting LC3-dependent autophagy. | Xie, YP., et al. 2018. Theranostics. 8: 5995-6007. PMID: 30613277
- Connection Between CDC20 Expression and Hepatocellular Carcinoma Prognosis. | Zhang, X., et al. 2021. Med Sci Monit. 27: e926760. PMID: 33788826
- CDC20 promotes bone formation via APC/C dependent ubiquitination and degradation of p65. | Du, Y., et al. 2021. EMBO Rep. 22: e52576. PMID: 34382737
- CDC20 regulates sensitivity to chemotherapy and radiation in glioblastoma stem cells. | Mao, DD., et al. 2022. PLoS One. 17: e0270251. PMID: 35737702
- CDC20-Mediated hnRNPU Ubiquitination Regulates Chromatin Condensation and Anti-Cancer Drug Response. | Wavelet-Vermuse, C., et al. 2022. Cancers (Basel). 14: PMID: 35954396
- Knockdown of CDC20 promotes adipogenesis of bone marrow-derived stem cells by modulating β-catenin. | Du, Y., et al. 2022. Stem Cell Res Ther. 13: 443. PMID: 36056439
- CDC20 inhibition alleviates fibrotic response of renal tubular epithelial cells and fibroblasts by regulating nuclear translocation of β-catenin. | He, J., et al. 2023. Biochim Biophys Acta Mol Basis Dis. 1869: 166663. PMID: 36764621
- Design, synthesis and biological evaluation of CDC20 inhibitors for treatment of triple-negative breast cancer. | Zhao, SF., et al. 2024. Eur J Med Chem. 268: 116204. PMID: 38364716
- RUNX1 regulates MCM2/CDC20 to promote COAD progression modified by deubiquitination of USP31. | Tian, W., et al. 2024. Sci Rep. 14: 13906. PMID: 38886545
- CCDC68 Maintains Mitotic Checkpoint Activation by Promoting CDC20 Integration into the MCC. | Li, Q., et al. 2024. Adv Sci (Weinh). 11: e2406009. PMID: 39018254
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cdc20 Antibody (41) | sc-136024 | 50 µg/0.5 ml | $322.00 |