CD72 Antibody (H-7): sc-7483
- CD72 Antibody (H-7) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-96 mapping at the N-terminus of CD72 of mouse origin
- recommended for detection of CD72 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD72 Antibody (H-7). This work is in progress.
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CD72 Antibody (H-7) is a mouse monoclonal IgG1 antibody that detects CD72 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. CD72 is a crucial transmembrane glycoprotein that plays a significant role in the regulation of B cell activation, acting as a negative regulator from the pro-B cell stage through to mature B cells. CD72 (H-7) antibody helps researchers study CD72′s ability to modulate immune responses; CD72 contains an immunoreceptor tyrosine-based inhibition motif (ITIM) that, upon tyrosine phosphorylation, recruits SH2-containing phosphatases such as SHP-1, leading to the downregulation of cell activation. This regulatory mechanism is vital for maintaining immune homeostasis, as evidenced by studies showing that CD72-deficient mice exhibit hyperproliferative B cells, which can result in autoimmune conditions. The human CD72 gene is located on chromosome 9p13.3, underscoring its evolutionary conservation and functional significance across species. Anti-CD72 antibody (H-7) is an essential tool for researchers investigating the intricate balance of immune cell activation and regulation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD72 Antibody (H-7) | sc-7483 | 200 µg/ml | $322.00 |