CD45RC Antibody (2Q1664): sc-70709
- CD45RC Antibody (2Q1664) is a rat monoclonal IgM provided at 100 µg/ml
- raised against CD45RC of mouse origin
- recommended for detection of CD45RC of mouse origin by WB, IP and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD45RC Antibody (2Q1664). This work is in progress.
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CD45RC Antibody (2Q1664) is a rat monoclonal IgM antibody that detects CD45RC in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). CD45RC, also known as PTPRC, is a transmembrane glycoprotein predominantly expressed in hematopoietic cells, where CD45RC (2Q1664) antibody plays a crucial role in immune response regulation. CD45RC functions as a phosphotyrosine phosphatase, essential for T cell activation. CD45RC activity is vital for inducing tyrosine phosphorylation by the T cell receptor (TCR)/CD3 complex, facilitating downstream signaling pathways critical for T cell activation and proliferation. CD45RC structure includes multiple isoforms generated through alternative splicing of exons 4, 5, and 6, resulting in variations in the extracellular domain while maintaining a conserved intracellular domain responsible for phosphatase activity. CD45RC interacts with key signaling molecules such as Lck, Fyn, and ZAP-70, which are part of the Src and Syk family of protein tyrosine kinases, underscoring its significance in T cell signaling and immune function.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD45RC Antibody (2Q1664) | sc-70709 | 100 µg/ml | $322.00 |