CD45R Antibody (HIS24): sc-19615

CD45R Antibody (HIS24) is a mouse monoclonal IgG2b kappa light chain antibody, specifically designed to target the CD45R protein. This transmembrane glycoprotein is ubiquitously expressed across hematopoietic cells and exists in multiple isoforms generated through alternative splicing of exons 4, 5, and 6, which affect its extracellular domain. Anti-CD45R antibody (HIS24) is raised against low density cells from AO/G rat Peyer′s patches, ensuring reactivity in both mouse and rat species when used in western blotting (WB), immunoprecipitation (IP), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM) applications. CD45R functions as a critical phosphotyrosine phosphatase, playing an essential role in the regulation of tyrosine phosphorylation initiated by the TCR/CD3 complex. This regulation is vital for the activation and signaling pathways of Src and Syk family kinases, including key proteins such as Lck, Fyn, and ZAP-70, which are substrates of CD45R. The conserved intracellular domain of CD45R ensures consistent phosphatase activity across different cell types, making CD45R a fundamental component in immune cell signaling and function. Understanding and utilizing CD45R (HIS24) monoclonal antibody is crucial for researchers studying immune responses, signaling mechanisms, and hematopoietic cell behavior, providing valuable insights into the regulation of immune system activities.

The preferred CD45 antibody is CD45 Antibody (35-Z6): sc-1178.