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RNA polymerase I (Pol I) is a multi-subunit complex responsible for catalyzing the transcription of DNA into RNA, specifically via the synthesis of ribosomal RNA precursors. CD3EAP, also known as ASE1, CAST or PAF49, is a 510 amino acid protein that localizes to the nucleus and belongs to the eukaryotic RPA34 RNA polymerase subunit family. Existing as two alternatively spliced isoforms, CD3EAP functions as a component of the Pol I complex, specifically exhibiting DNA-dependent RNA polymerase activity and effectively catalyzing the the conversion of a nucleoside triphosphate into a diphosphate, thereby transcribing DNA into RNA. Isoform 2 of CD3EAP may be a component of the T cell receptor (TCR) complex and is subject to tyrosine phosphorylation in response to TCR stimulation. Both isoforms of CD3EAP are subject to DNA damage-dependent phosphorylation, probably by ATM or ATR.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps CD3EAP (A-4) | sc-393106 | 200 µg/ml | $316.00 | |||
CD3EAP (A-4): m-IgGκ BP-HRP Kit | sc-535704 | 200 µg Ab; 40 µg BP | $354.00 | |||
CD3EAP (A-4): m-IgG2b BP-HRP Kit | sc-549473 | 200 µg Ab; 10 µg BP | $354.00 | |||
Anticorps CD3EAP (A-4) X | sc-393106 X | 200 µg/0.1 ml | $316.00 |