CD100 Antibody (148-2D12): sc-21780

CD100 Antibody (148-2D12) is a mouse monoclonal IgG1 antibody that detects CD100 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). CD100, also known as SEMA4D, is a transmembrane protein that plays a crucial role in the immune system, distinguishing CD100 as the only member of the semaphorin family expressed in immune cells. CD100 is vital for T cell proliferation and B cell aggregation, facilitating immune responses. CD100 interacts with CD72, a receptor that typically inhibits B cell activity; upon binding, CD100 negates this inhibitory signal, leading to the activation of downstream signaling pathways that enhance B cell responses. The importance of this interaction lies in its ability to modulate immune responses, which can have significant implications for understanding autoimmune diseases and developing therapeutic strategies. The gene encoding human CD100 is located on chromosome 9q22-q31, highlighting CD100′s evolutionary conservation and functional significance across species. Anti-CD100 antibody (148-2D12) is an essential tool for researchers investigating the complexities of immune regulation and the mechanisms underlying immune cell interactions.

The preferred CD100 antibody is CD100 Antibody (C-3): sc-390675.