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In eukaryotes, the majority of mRNAs have an m(7)G cap, which is added cotranscriptionally and plays a critical role in many aspects of mRNA metabolism. The effect of the cap on translation is mediated by the initiation factor eIF-4F, whereas the effect on pre-mRNA splicing involves a nuclear complex (CBC). CBC consists of two cap binding proteins CBP20 and CBP80, which mediate the stimulatory functions of the cap in pre-mRNA splicing, 3′ end formation and U snRNA export. The genes CBC1 and CBC2 encode CBP80 and CBP20, respectively CBP80 comprises three domains, each containing a MIF4G domain. CBP20 has an RNAP fold and associates with the second and third domains of CBP80. CBP also plays a role in nonsense-mediated decay (NMD), which eliminates mRNAs, which prematurely terminate translation. CBP80-bound mRNA undergoes a "pioneer" round of translation before CBP80-CBP20 are replaced by eIF4E, and Upf2 and Upf3 proteins.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps CBP80 (G-4) | sc-271305 | 200 µg/ml | $316.00 | |||
CBP80 (G-4): m-IgG Fc BP-HRP Kit | sc-537606 | 200 µg Ab; 10 µg BP | $354.00 | |||
CBP80 (G-4): m-IgGκ BP-HRP Kit | sc-534921 | 200 µg Ab; 40 µg BP | $354.00 | |||
CBP80 (G-4): m-IgG1 BP-HRP Kit | sc-545257 | 200 µg Ab; 20 µg BP | $354.00 | |||
Anticorps CBP80 (G-4) X | sc-271305 X | 200 µg/0.1 ml | $316.00 |