caveolin-3 Antibody (C-2): sc-55518

caveolin-3 Antibody (C-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects caveolin-3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-caveolin-3 antibody (C-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Caveolin-3 is primarily located in the plasma membrane and is a crucial component of caveolae, which are flask-shaped invaginations that play significant roles in cellular processes such as endocytosis and signal transduction. These structures are essential for compartmentalizing signaling molecules, including G protein-coupled receptors, and facilitate macromolecule transcytosis like low-density lipoproteins across endothelial cells. Caveolin-3 presence in caveolae maintains cellular homeostasis and regulates various signaling pathways, making caveolin-3 important in cardiovascular health and disease. Caveolin-3 also interacts with caveolin-1 and caveolin-2, which share structural similarities and functional roles, highlighting caveolin-3′s significance in cellular signaling and membrane dynamics.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

caveolin-3 Antibody (C-2) References:

1. Targeting caveolin-3 for the treatment of diabetic cardiomyopathy.  |  Murfitt, L., et al. 2015. Pharmacol Ther. 151: 50-71. PMID: 25779609
2. Caveolin-3 Microdomain: Arrhythmia Implications for Potassium Inward Rectifier and Cardiac Sodium Channel.  |  Vaidyanathan, R., et al. 2018. Front Physiol. 9: 1548. PMID: 30473666
3. A Role for Caveolin-3 in the Pathogenesis of Muscular Dystrophies.  |  Pradhan, BS. and Prószyński, TJ. 2020. Int J Mol Sci. 21: PMID: 33228026
4. The World of Protein Interactions: Defining the Caveolin 3 Cardiac Interactome.  |  Van Eyk, JE. 2021. Circ Res. 128: 720-722. PMID: 33734816
5. Caveolin-3 and Arrhythmias: Insights into the Molecular Mechanisms.  |  He, M., et al. 2022. J Clin Med. 11: PMID: 35329921
6. Caveolin 3 suppresses phosphorylation-dependent activation of sarcolemmal nNOS.  |  Ohsawa, Y., et al. 2022. Biochem Biophys Res Commun. 628: 84-90. PMID: 36084555
7. Functional LTCC-β2AR Complex Needs Caveolin-3 and Is Disrupted in Heart Failure.  |  Sanchez-Alonso, JL., et al. 2023. Circ Res. 133: 120-137. PMID: 37313722
8. Caveolin-3 loss linked with the P104L LGMD-1C mutation modulates skeletal muscle mTORC1 signalling and cholesterol homeostasis.  |  Shah, DS., et al. 2023. J Cachexia Sarcopenia Muscle. 14: 2310-2326. PMID: 37671684
9. Caveolin-3 negatively regulates endocytic recycling of cardiac KATP channels.  |  Huo, JY., et al. 2023. Am J Physiol Cell Physiol. 325: C1106-C1118. PMID: 37746698
10. Cysteine post-translational modifications regulate protein interactions of caveolin-3.  |  Ashford, F., et al. 2024. FASEB J. 38: e23535. PMID: 38466300

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-caveolin-3 Antibody (C-2) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-caveolin-3 Antibody (C-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

caveolin-3 Antibody (C-2) Specifications

Alternate Product Name: caveolin-3

Product Clone Name: C-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 3-40

Epitope Target: caveolin-3

Epitope Species: mouse

Product Reactivity/Detection: caveolin-3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for caveolin-3 Antibody (C-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred caveolin-3 antibody is caveolin-3 Antibody (A-3): sc-5310.