CARM1 Antibody (B-10): sc-398818
- CARM1 Antibody (B-10) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 7-27 at the N-terminus of CARM1 of mouse origin
- recommended for detection of CARM1 of mouse and rat origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-398818 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CARM1 Antibody (B-10) for WB applications. These reagents are now offered in bundles with CARM1 Antibody (B-10) (see ordering information below).
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SEE ALSO...
CARM1 Antibody (B-10) is a mouse monoclonal IgG2a antibody that detects CARM1 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CARM1, also known as protein arginine N-methyltransferase 4 (PRMT4), is a crucial 585 amino acid protein located in both the nucleus and cytoplasm, playing a significant role in the regulation of gene expression. CARM1′s primary function involves the methylation of arginine residues on target proteins, which is essential for processes such as mRNA stability and transcriptional regulation. CARM1′s cellular location enables interaction with various transcription factors and coactivators, thereby influencing gene expression in response to cellular signals. Additionally, CARM1′s activity is intricately regulated by post-translational modifications, including phosphorylation, which can inhibit methyltransferase function. This regulation is vital for maintaining the balance of gene expression and ensuring proper cellular responses. Anti-CARM1 antibody (B-10) serves as an invaluable tool for researchers studying the complex mechanisms of gene regulation and the role of arginine methylation in cellular processes.
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CARM1 Antibody (B-10) References:
- AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy. | Shin, HJ., et al. 2016. Nature. 534: 553-7. PMID: 27309807
- CARM1/PRMT4: Making Its Mark beyond Its Function as a Transcriptional Coactivator. | Suresh, S., et al. 2021. Trends Cell Biol. 31: 402-417. PMID: 33485722
- The circular RNA circHMGB2 drives immunosuppression and anti-PD-1 resistance in lung adenocarcinomas and squamous cell carcinomas via the miR-181a-5p/CARM1 axis. | Zhang, LX., et al. 2022. Mol Cancer. 21: 110. PMID: 35525959
- CARM1 arginine methyltransferase as a therapeutic target for cancer. | Santos, M., et al. 2023. J Biol Chem. 299: 105124. PMID: 37536629
- Arginine methylation of PPP1CA by CARM1 regulates glucose metabolism and affects osteogenic differentiation and osteoclastic differentiation. | Zhang, L., et al. 2023. Clin Transl Med. 13: e1369. PMID: 37649137
- CARM1 drives mitophagy and autophagy flux during fasting-induced skeletal muscle atrophy. | Stouth, DW., et al. 2024. Autophagy. 20: 1247-1269. PMID: 38018843
- Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1. | Garbutt, TA., et al. 2024. Circulation. 149: 1501-1515. PMID: 38223978
- CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A. | Feng, D., et al. 2024. Protein Cell. 15: 744-765. PMID: 38476024
- CARM1 hypermethylates the NuRD chromatin remodeling complex to promote cell cycle gene expression and breast cancer development. | Chen, X., et al. 2024. Nucleic Acids Res. 52: 6811-6829. PMID: 38676947
- CARM1 phosphorylation at S595 by p38γ MAPK drives ROS-mediated cellular senescence. | Cho, Y. and Kim, YK. 2024. Redox Biol. 76: 103344. PMID: 39265499
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CARM1 Antibody (B-10) | sc-398818 | 200 µg/ml | $322.00 | |||
CARM1 Antibody (B-10): m-IgG Fc BP-HRP Bundle | sc-538527 | 200 µg Ab; 10 µg BP | $361.00 | |||
CARM1 Antibody (B-10): m-IgGκ BP-HRP Bundle | sc-536155 | 200 µg Ab; 40 µg BP | $361.00 | |||
CARM1 Antibody (B-10): m-IgG2a BP-HRP Bundle | sc-548330 | 200 µg Ab; 10 µg BP | $361.00 | |||
CARM1 (B-10) Neutralizing Peptide | sc-398818 P | 100 µg/0.5 ml | $69.00 | |||
CARM1 Antibody (B-10) X | sc-398818 X | 200 µg/0.1 ml | $322.00 |