CARD 8 Antibody (2108C2a): sc-81213

CARD 8 Antibody (2108C2a) is a mouse monoclonal IgG1 kappa light chain antibody that detects CARD 8 protein of human origin by western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Anti-CARD 8 antibody (2108C2a) is available as a non-conjugated monoclonal isotype antibody. CARD 8 protein, also known as DACAR, NDPP1, TUCAN, or CARDINAL, is a 431 amino acid protein predominantly expressed in lung, ovary, testis, and placenta, where CARD 8 plays a crucial role in regulating cellular responses mediated by NF-κB activation. Such regulation is vital for maintaining cellular homeostasis and modulating inflammatory responses, making CARD 8 an important player in apoptosis and chronic inflammatory disorders. CARD 8 interacts with caspase-1, serving as a negative regulator of its activity, which is essential for controlling inflammatory processes. CARD 8 has been shown to interact with IKKγ and FHL-2, further highlighting CARD 8′s role in complex signaling pathways that influence cell survival and inflammation.

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CARD 8 Antibody (2108C2a) References:

1. CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways.  |  Bouchier-Hayes, L., et al. 2001. J Biol Chem. 276: 44069-77. PMID: 11551959
2. TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation.  |  Stilo, R., et al. 2002. FEBS Lett. 521: 165-9. PMID: 12067710
3. CARDINAL roles in apoptosis and NFkappaB activation.  |  Bouchier-Hayes, L. and Martin, SJ. 2004. Vitam Horm. 67: 133-47. PMID: 15110175
4. CARD proteins as therapeutic targets in cancer.  |  Damiano, JS. and Reed, JC. 2004. Curr Drug Targets. 5: 367-74. PMID: 15134219
5. TUCAN/CARDINAL/CARD8 and apoptosis resistance in non-small cell lung cancer cells.  |  Checinska, A., et al. 2006. BMC Cancer. 6: 166. PMID: 16796750
6. TUCAN (CARD8) genetic variants and inflammatory bowel disease.  |  McGovern, DP., et al. 2006. Gastroenterology. 131: 1190-6. PMID: 17030188
7. The expression of TUCAN, an inhibitor of apoptosis protein, in patients with advanced non-small cell lung cancer treated with chemotherapy.  |  Checinska, A., et al. 2006. Anticancer Res. 26: 3819-24. PMID: 17094407
8. Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease.  |  Henckaerts, L., et al. 2007. Gut. 56: 1536-42. PMID: 17595233
9. Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity.  |  Fontalba, A., et al. 2007. J Immunol. 179: 4867-73. PMID: 17878386

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CARD 8 Antibody (2108C2a) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-CARD 8 Antibody (2108C2a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CARD 8 Antibody (2108C2a) Specifications

Alternate Product Name: CARD 8

Product Clone Name: 2108C2a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: CARD 8

Epitope Species: human

Product Reactivity/Detection: CARD 8

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, FCM

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for CARD 8 Antibody (2108C2a): N/A