The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is a ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes designated α, β, γ and δ, which may or may not be co-expressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal antibody leads to a 10-40 fold increase in CaMKIV activity. An additional kinase, CaMKK, functions to activate CaMKI through the specific phosphorylation of the regulatory Threonine residue at position 177.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps CaMKI (D-9) | sc-377418 | 200 µg/ml | $316.00 | |||
CaMKI (D-9): m-IgG Fc BP-HRP Kit | sc-551175 | 200 µg Ab; 10 µg BP | $354.00 | |||
CaMKI (D-9): m-IgG1 BP-HRP Kit | sc-551176 | 200 µg Ab; 20 µg BP | $354.00 | |||
CaMKI (D-9) peptide neutralisant | sc-377418 P | 100 µg/0.5 ml | $68.00 |