CA XIII Antibody (G-11): sc-376753
- CA XIII Antibody (G-11) is a mouse monoclonal IgG1 κ CA XIII antibody provided at 200 µg/ml
- raised against amino acids 32-81 mapping near the N-terminus of CA XIII of human origin
- CA XIII Antibody (G-11) is recommended for detection of CA XIII of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-CA XIII Antibody (G-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for CA XIII Antibody (G-11) for WB applications. This reagent is now offered in a bundle with CA XIII Antibody (G-11) (see ordering information below).
CA XIII Antibody (G-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects CA XIII of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CA XIII (G-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Carbonic anhydrases (CAs) are a significant family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide, playing crucial roles in numerous physiological processes such as respiration, acid-base balance, and the formation of various bodily fluids. CA XIII, also known as carbonate dehydratase XIII, is predominantly localized in the cytoplasm of tissues such as the spleen, prostate, thymus, ovary, testis, colon, and small intestine, which is vital for maintaining pH homeostasis and facilitating metabolic processes in these organs. CA XIII expression may also be linked to embryogenesis, highlighting potential importance in developmental biology. CA XIII exhibits significant homology with other family members, including CA I, CA II, and CA III, suggesting overlapping functions or regulatory mechanisms. Efficient inhibitors of CA XIII activity, such as sulfanilyl-sulfonamide type inhibitors, have been identified, providing potential therapeutic avenues for conditions related to dysregulated carbonic anhydrase activity.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CA XIII Antibody (G-11) References:
- Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family. | Lehtonen, J., et al. 2004. J Biol Chem. 279: 2719-27. PMID: 14600151
- Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design. | Lehtonen, JM., et al. 2004. Bioorg Med Chem Lett. 14: 3757-62. PMID: 15203157
- Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. | Innocenti, A., et al. 2004. Bioorg Med Chem Lett. 14: 5435-9. PMID: 15454240
- Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa. | Kummola, L., et al. 2005. BMC Cancer. 5: 41. PMID: 15836783
- Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice. | Pan, P., et al. 2006. J Physiol. 571: 319-27. PMID: 16396925
- Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue. | Winum, JY., et al. 2006. J Med Chem. 49: 7024-31. PMID: 17125255
- Carbonic anhydrases as targets for medicinal chemistry. | Supuran, CT. and Scozzafava, A. 2007. Bioorg Med Chem. 15: 4336-50. PMID: 17475500
- Carbonic anhydrases as drug targets--an overview. | Supuran, CT. 2007. Curr Top Med Chem. 7: 825-33. PMID: 17504127
- Characterization and inhibition of the recently discovered carbonic anhydrase isoforms CA XIII, XIV and XV. | Hilvo, M., et al. 2007. Curr Top Med Chem. 7: 893-9. PMID: 17504134
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CA XIII Antibody (G-11) | sc-376753 | 200 µg/ml | $322.00 | |||
CA XIII Antibody (G-11): m-IgG Fc BP-HRP Bundle | sc-526046 | 200 µg Ab; 10 µg BP | $361.00 | |||
CA XIII Antibody (G-11) AC | sc-376753 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CA XIII Antibody (G-11) HRP | sc-376753 HRP | 200 µg/ml | $322.00 | |||
CA XIII Antibody (G-11) FITC | sc-376753 FITC | 200 µg/ml | $336.00 | |||
CA XIII Antibody (G-11) PE | sc-376753 PE | 200 µg/ml | $349.00 | |||
CA XIII Antibody (G-11) Alexa Fluor® 488 | sc-376753 AF488 | 200 µg/ml | $364.00 | |||
CA XIII Antibody (G-11) Alexa Fluor® 546 | sc-376753 AF546 | 200 µg/ml | $364.00 | |||
CA XIII Antibody (G-11) Alexa Fluor® 594 | sc-376753 AF594 | 200 µg/ml | $364.00 | |||
CA XIII Antibody (G-11) Alexa Fluor® 647 | sc-376753 AF647 | 200 µg/ml | $364.00 | |||
CA XIII Antibody (G-11) Alexa Fluor® 680 | sc-376753 AF680 | 200 µg/ml | $364.00 | |||
CA XIII Antibody (G-11) Alexa Fluor® 790 | sc-376753 AF790 | 200 µg/ml | $364.00 |