Molecular structure of BW A4C, CAS Number: 106328-57-8
BW A4C (CAS 106328-57-8)
Alternate Names:
N-[(E)-3-(3-Phenoxyphenyl)prop-2-enyl]acetohydroxamic acid
Application:
BW A4C is a selective 5-LO (5-lipoxygenase) inhibitor
CAS Number:
106328-57-8
Molecular Weight:
283.32
Molecular Formula:
C17H17NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
BW A4C is a selective 5-LO (5-lipoxygenase) inhibitor. BW A4C inhibits synthesis of LTB4.
BW A4C (CAS 106328-57-8) References
- Mouse macrophages release a neutrophil chemotactic mediator following stimulation by staphylococcal enterotoxin type A. | Desouza, IA., et al. 2001. Inflamm Res. 50: 206-12. PMID: 11392608
- Guinea pig whole blood 5-lipoxygenase assay: utility in the assessment of potential 5-lipoxygenase inhibitors. | Spaethe, SM., et al. 1992. Biochem Pharmacol. 43: 377-82. PMID: 1310855
- 5-lipoxygenase inhibitors and their anti-inflammatory activities. | Batt, DG. 1992. Prog Med Chem. 29: 1-63. PMID: 1475368
- Selective 5-lipoxygenase inhibitor BW A4C does not influence progression of tissue injury in a canine model of regional myocardial ischaemia and reperfusion. | Maxwell, MP., et al. 1991. J Cardiovasc Pharmacol. 17: 539-45. PMID: 1711618
- Application of (methyl-11C)-methionine in the multicellular spheroid system. | Gáti, I., et al. 1991. J Nucl Med. 32: 2258-65. PMID: 1744712
- Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. | Payne, AN., et al. 1991. Agents Actions Suppl. 34: 189-99. PMID: 1793063
- The effects of a 5-lipoxygenase inhibitor, BW A4C, on the acute response to inhaled PAF in man. | Spencer, DA., et al. 1991. Ann N Y Acad Sci. 629: 430-1. PMID: 1952568
- Involvement of leukotrienes in acute gastric damage. | Boughton-Smith, NK. 1989. Methods Find Exp Clin Pharmacol. 11 Suppl 1: 53-9. PMID: 2657289
- Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: biochemical assessment in vitro and ex vivo. | Tateson, JE., et al. 1988. Br J Pharmacol. 94: 528-39. PMID: 2840160
- Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: effects on acute inflammatory responses. | Higgs, GA., et al. 1988. Br J Pharmacol. 94: 547-51. PMID: 2840161
- Inactivation of soybean lipoxygenase by lipoxygenase inhibitors in the presence of 15-hydroperoxyeicosatetraenoic acid. | Reynolds, CH. 1988. Biochem Pharmacol. 37: 4531-7. PMID: 3144281
- Failure of the inhibition of rat gastric mucosal 5-lipoxygenase by novel acetohydroxamic acids to prevent ethanol-induced damage. | Boughton-Smith, NK. and Whittle, BJ. 1988. Br J Pharmacol. 95: 155-62. PMID: 3146394
- Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: effects on bronchial anaphylaxis in anaesthetized guinea-pigs. | Payne, AN., et al. 1988. Br J Pharmacol. 94: 540-6. PMID: 3395791
- BW A4C and other hydroxamic acids are potent inhibitors of linoleic acid 8R-dioxygenase of the fungus Gaeumannomyces graminis. | Brodowsky, ID., et al. 1994. Eur J Pharmacol. 254: 43-7. PMID: 8206115
- Effects of a lipoxygenase inhibitor on digoxin-induced cardiac arrhythmias in the isolated perfused guinea-pig heart. | Gök, S., et al. 1997. Gen Pharmacol. 29: 789-92. PMID: 9347327
Inhibitor of:
5-LO.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BW A4C, 5 mg | sc-210981 | 5 mg | $137.00 | |||
BW A4C, 25 mg | sc-210981A | 25 mg | $660.00 |