BM88 Antibody (G-7): sc-398447

BM88 Antibody (G-7) is a mouse monoclonal IgM kappa antibody that detects BM88 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-BM88 antibody (G-7) is available as the non-conjugated form. BM88 protein, also known as CEND1 (cell cycle exit and neuronal differentiation protein 1), plays a crucial role in neuroblastoma cell differentiation and is characterized as a single-pass type IV membrane protein that is neuron-specific. BM88 structure includes a central proline-rich region with four PxxP motifs, which are known to interact with SRC homology-3 (SH3) domains, and a putative C-terminal transmembrane region. BM88 contains several potential sites for post-translational modifications such as N-glycosylation, myristoylation, and phosphorylation, which are essential for functional regulation and interactions within the cell. BM88 is implicated in a novel signaling mechanism that modulates calcium release from inositol 1,4,5-trisphosphate-sensitive stores, contributing to anti-proliferative and anti-apoptotic functions. BM88 serves as a significant molecular target for histone deacetylase inhibition, with transcription being induced by trichostatin-A, highlighting importance in cellular processes and potential therapeutic applications.

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BM88 Antibody (G-7) References:

1. Purification and characterization of neuron-specific surface antigen defined by monoclonal antibody BM88.  |  Patsavoudi, E., et al. 1991. J Neurochem. 56: 782-8. PMID: 1704420
2. BM88/Cend1 is involved in histone deacetylase inhibition-mediated growth arrest and differentiation of neuroblastoma cells.  |  Politis, PK., et al. 2008. FEBS Lett. 582: 741-8. PMID: 18258204
3. Hidden layers of human small RNAs.  |  Kawaji, H., et al. 2008. BMC Genomics. 9: 157. PMID: 18402656
4. BM88/Cend1 expression levels are critical for proliferation and differentiation of subventricular zone-derived neural precursor cells.  |  Katsimpardi, L., et al. 2008. Stem Cells. 26: 1796-807. PMID: 18499894
5. BM88/Cend1 regulates stimuli-induced intracellular calcium mobilization.  |  Masgrau, R., et al. 2009. Neuropharmacology. 56: 598-609. PMID: 19061903
6. Impaired cerebellar development and deficits in motor coordination in mice lacking the neuronal protein BM88/Cend1.  |  Sergaki, MC., et al. 2010. Mol Cell Neurosci. 44: 15-29. PMID: 20153830
7. The BM88 antigen, a novel neuron-specific molecule, enhances the differentiation of mouse neuroblastoma cells.  |  Mamalaki, A., et al. 1995. J Biol Chem. 270: 14201-8. PMID: 7775480

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BM88 Antibody (G-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-BM88 Antibody (G-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BM88 Antibody (G-7) Specifications

Alternate Product Name: BM88

Product Clone Name: G-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 80-95

Epitope Target: BM88

Epitope Species: human

Product Reactivity/Detection: BM88

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for BM88 Antibody (G-7): P: Blocking Peptide