Anticorps BIG1 (A-11): sc-376866
- L'Anticorps BIG1 (A-11) est un monoclonal de souris IgG1 κ, cité dans 2 publications, fourni en 200 µg/ml
- dirigé contre les acides aminés 285-419 dans une région interne de BIG1 d'origine human
- recommandé pour la détection de BIG1 d'origine human par WB, IP, IF, IHC(P) et ELISA
- m-IgG Fc BP-HRP et 1 BP-HRP">m-IgG1 BP-HRP sont les réactifs de détection secondaire préférés pour BIG1 Antibody (A-11) for WB and IHC(P) applications. Ces réactifs sont désormais proposés en lots avec BIG1 Antibody (A-11)(voir les informations de commande ci-dessous).
ACCÈS RAPIDE AUX LIENS
Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects Golgi structure and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the Golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps BIG1 (A-11) | sc-376866 | 200 µg/ml | $316.00 | |||
BIG1 (A-11): m-IgG Fc BP-HRP Kit | sc-540657 | 200 µg Ab; 10 µg BP | $354.00 | |||
BIG1 (A-11): m-IgG1 BP-HRP Kit | sc-542275 | 200 µg Ab; 20 µg BP | $354.00 |