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T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory molecules. One such molecule, B7-H3 (B7-homolog 3, also designated B7RP-2) belongs to the B7 Immunoglobulin superfamily. Soluble B7-H3 binds a putative receptor on activated T-cells that is distinct from CD28, CTLA-4, ICOS and PD-1. Widely expressed on nonlymphoid tissues, B7-H3 costimulates proliferation of both CD4+ and CD8+ T cells. The ability of B7-H3 to stimulate Th1 and cytotoxic-T cell responses suggest that it may have antitumor activity. B7-H3 interactions may play a role in regulating cell-mediated immune responses against cancer, implicating B7-H3 as a potential therapeutic tool.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps B7-H3 (D-8) | sc-398444 | 200 µg/ml | $316.00 | |||
B7-H3 (D-8): m-IgGκ BP-HRP Kit | sc-536061 | 200 µg Ab; 40 µg BP | $354.00 | |||
B7-H3 (D-8): m-IgG2b BP-HRP Kit | sc-549508 | 200 µg Ab; 10 µg BP | $354.00 | |||
B7-H3 (D-8) peptide neutralisant | sc-398444 P | 100 µg/0.5 ml | $68.00 |