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The serine proteinase inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Antithrombin III (ATIII), an extracellular plasma protein, is a crucial serine protease inhibitor that regulates the coagulation cascade in blood. The inhibitory activity of ATIII is amplified in the presence of heparin. ATIII inhibits Thrombin and Factors IXa, Xa and XIa. Defects in the gene SERPINC1, which encodes for ATIII, can cause ATIII deficiency, an autosomal dominant disease which is a risk factor for hereditary thrombophilia.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps ATIII (A-6) | sc-393867 | 200 µg/ml | $316.00 | |||
ATIII (A-6): m-IgGκ BP-HRP Kit | sc-535912 | 200 µg Ab; 40 µg BP | $354.00 | |||
ATIII (A-6): m-IgG3 BP-HRP Kit | sc-550315 | 200 µg Ab; 40 µg BP | $354.00 | |||
ATIII (A-6) peptide neutralisant | sc-393867 P | 100 µg/0.5 ml | $68.00 |