Anticorps APC4 (G-1): sc-374173
- L'Anticorps APC4 (G-1) est un monoclonal de souris IgG1 (chaîne légère kappa) fourni en 200 µg/ml
- dirigé contre les acides aminés 509-806 situés près de la région C-terminus de APC4 d'origine human
- recommandé pour la détection de APC4 d'origine mouse, rat et human par WB, IP, IF et ELISA
- m-IgG Fc BP-HRP, 1 BP-HRP">m-IgG1 BP-HRP et m-IgGκ BP-HRP sont les réactifs de détection secondaire préférés pour l'anticorps APC4 (G-1) pour les applications WB. Ces réactifs sont désormais proposés en lots avec l'anticorps APC4 (G-1)(voir les informations de commande ci-dessous).
The anaphase-promoting complex (APC) is composed of more than ten subunits, including APC1, APC2, APC4, APC5, APC7, APC8, APC10, and APC11. The APC acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to and activate the cyclin-ubiquitination activity of APCs. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC, thus preventing APC activation. APC4, also known as ANAPC4, is an 808 amino acid component of the APC.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps APC4 (G-1) | sc-374173 | 200 µg/ml | $316.00 | |||
APC4 (G-1): m-IgG Fc BP-HRP Kit | sc-537926 | 200 µg Ab; 10 µg BP | $354.00 | |||
APC4 (G-1): m-IgGκ BP-HRP Kit | sc-535404 | 200 µg Ab; 40 µg BP | $354.00 | |||
APC4 (G-1): m-IgG1 BP-HRP Kit | sc-545450 | 200 µg Ab; 20 µg BP | $354.00 |