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The annexin family of calcium-binding proteins is composed of at least ten mammalian genes. It is characterized by a conserved core domain which binds to phospholipids in a Ca++-dependent manner and a unique amino terminal region which may confer binding specificity. Annexin family members have been implicated as regulators of such diverse processes as ion flux, endocytosis and exocytosis, and cellular adhesion. For example, the crystal structure of Annexin III has suggested a hydrophilic amino terminus with possible Ca++ channel activity. Similarly, Annexin V has ion channel properties. Annexin IV, also referred to as endonexin, functions to regulate Cl- flux by mediating calmodulin kinase II (CaMKII) activity and Annexin V has been shown to regulate PKC activity.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Annexin IV (H-2) | sc-374254 | 200 µg/ml | $316.00 | |||
Annexin IV (H-2): m-IgGκ BP-HRP Kit | sc-535430 | 200 µg Ab; 40 µg BP | $354.00 | |||
Annexin IV (H-2): m-IgG2b BP-HRP Kit | sc-549415 | 200 µg Ab; 10 µg BP | $354.00 | |||
Annexin IV (H-2) peptide neutralisant | sc-374254 P | 100 µg/0.5 ml | $68.00 |