α-Dystrobrevin Antibody (D-9): sc-271630

α-Dystrobrevin Antibody (D-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects alpha-Dystrobrevin of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-alpha-Dystrobrevin antibody (D-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. alpha-Dystrobrevin plays a crucial role in the dystrophin complex, which is essential for maintaining muscle integrity; disruption is linked to Duchenne muscular dystrophy and related disorders. alpha-Dystrobrevin is primarily localized to the cytoplasmic side of the sarcolemma and is particularly concentrated at the neuromuscular junctions in skeletal muscle, highlighting importance in muscle function and synapse maturation. Alternative splicing of alpha-Dystrobrevin results in several isoforms, including γ-Dystrobrevin, δ-Dystrobrevin, ε-Dystrobrevin, and ζ-Dystrobrevin, which may have distinct roles in various tissues. These isoforms underscore the complexity of dystrophin-associated protein interactions and significance in cellular signaling and muscle physiology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

α-Dystrobrevin Antibody (D-9) References:

1. Different dystrophin-like complexes are expressed in neurons and glia.  |  Blake, DJ., et al. 1999. J Cell Biol. 147: 645-58. PMID: 10545507
2. Assembly of multiple dystrobrevin-containing complexes in the kidney.  |  Loh, NY., et al. 2000. J Cell Sci. 113 (Pt 15): 2715-24. PMID: 10893187
3. Cellular and molecular properties of alpha-dystrobrevin in skeletal muscle.  |  Enigk, RE. and Maimone, MM. 2001. Front Biosci. 6: D53-64. PMID: 11145920
4. A novel mechanism for modulating synaptic gene expression: differential localization of alpha-dystrobrevin transcripts in skeletal muscle.  |  Newey, SE., et al. 2001. Mol Cell Neurosci. 17: 127-40. PMID: 11161474
5. Molecular, genetic and physiological characterisation of dystrobrevin-like (dyb-1) mutants of Caenorhabditis elegans.  |  Gieseler, K., et al. 2001. J Mol Biol. 307: 107-17. PMID: 11243807
6. Characterization of human alpha-dystrobrevin isoforms in HL-60 human promyelocytic leukemia cells undergoing granulocytic differentiation.  |  Kulyte, A., et al. 2002. Mol Biol Cell. 13: 4195-205. PMID: 12475945
7. Deficiency of the syntrophins and alpha-dystrobrevin in patients with inherited myopathy.  |  Jones, KJ., et al. 2003. Neuromuscul Disord. 13: 456-67. PMID: 12899872
8. Beta-dystrobrevin interacts directly with kinesin heavy chain in brain.  |  Macioce, P., et al. 2003. J Cell Sci. 116: 4847-56. PMID: 14600269
9. Differential spatio-temporal expression of alpha-dystrobrevin-1 during mouse development.  |  Lien, CF., et al. 2004. Gene Expr Patterns. 4: 583-93. PMID: 15261837
10. beta-dystrobrevin, a member of the dystrophin-related protein family.  |  Blake, DJ., et al. 1998. Proc Natl Acad Sci U S A. 95: 241-6. PMID: 9419360

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-α-Dystrobrevin Antibody (D-9) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-α-Dystrobrevin Antibody (D-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

α-Dystrobrevin Antibody (D-9) Specifications

Alternate Product Name: α-Dystrobrevin

Product Clone Name: D-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 301-600 deletion 366-422

Epitope Target: α-Dystrobrevin

Epitope Species: human

Product Reactivity/Detection: all isoforms of α-Dystrobrevin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for α-Dystrobrevin Antibody (D-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Dystrobrevin antibody is Dystrobrevin Antibody (C-6): sc-271874.