Adipsin Antibody (D-8): sc-376015

Adipsin Antibody (D-8) is a mouse monoclonal IgG1 antibody that detects Adipsin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Adipsin, also known as complement Factor D, plays a crucial role in the complement system, which is essential for immune response and inflammation regulation. This serine protease is primarily secreted by adipose tissue, where Adipsin is involved in the cleavage of complement factor B, facilitating the activation of the alternative pathway of the complement system. Adipsin′s importance extends beyond enzymatic function; anti-Adipsin antibody (D-8) has helped reveal connections to metabolic processes and obesity-related conditions. Low levels of Adipsin have been observed in obese mice with hypothalamic defects, suggesting a potential link between Adipsin expression and metabolic health. The presence of Adipsin in monocytes and macrophages highlights Adipsin′s role in immune modulation, making Adipsin antibody (D-8) a significant tool for research in both metabolic and immune-related studies.

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Adipsin Antibody (D-8) References:

1. Effects of complement factor D deficiency on the renal disease of MRL/lpr mice.  |  Elliott, MK., et al. 2004. Kidney Int. 65: 129-38. PMID: 14675043
2. Eliminating complement factor D reduces photoreceptor susceptibility to light-induced damage.  |  Rohrer, B., et al. 2007. Invest Ophthalmol Vis Sci. 48: 5282-9. PMID: 17962484
3. Plasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes Mellitus.  |  Tafere, GG., et al. 2020. Diabetes Metab Syndr Obes. 13: 1855-1861. PMID: 32547147
4. Adipsin of the Alternative Complement Pathway Is a Potential Predictor for Preeclampsia in Early Pregnancy.  |  Liu, M., et al. 2021. Front Immunol. 12: 702385. PMID: 34671343
5. Adipsin alleviates cardiac microvascular injury in diabetic cardiomyopathy through Csk-dependent signaling mechanism.  |  Zhang, X., et al. 2023. BMC Med. 21: 197. PMID: 37237266
6. Serum proteomic identification and validation of two novel atherosclerotic aortic aneurysm biomarkers, profilin 1 and complement factor D.  |  Murakami, Y., et al. 2023. Proteome Sci. 21: 11. PMID: 37543598
7. Quantitation of complement factor D in human serum by a solid-phase radioimmunoassay.  |  Barnum, SR., et al. 1984. J Immunol Methods. 67: 303-9. PMID: 6561229
8. Inhibition of complement alternative pathway in mice with Fab antibody to recombinant adipsin/factor D.  |  Pascual, M., et al. 1993. Eur J Immunol. 23: 1389-92. PMID: 8500532
9. Effect of body weight and caloric restriction on serum complement proteins, including Factor D/adipsin: studies in anorexia nervosa and obesity.  |  Pomeroy, C., et al. 1997. Clin Exp Immunol. 108: 507-15. PMID: 9182900
10. Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity.  |  Jing, H., et al. 1998. J Mol Biol. 282: 1061-81. PMID: 9753554

The preferred Adipsin antibody is Adipsin Antibody (D10/4): sc-47683.