Anticorps Nicotinic Acetylcholine Receptor epsilon/CHRNE (D-6): sc-376826

Members of the ligand-gated ion channel receptor family are characterized by their fast transmitting response to neurotransmitters. Two important members of this family are the nicotinic acetylcholine and glutamate receptors, both of which are composed of five homologous subunits forming a transmembrane aqueous pore. These transmembrane receptors change conformation in response to their cognate neurotransmitter. Nicotinic acetylcholine receptors (AChRs) are found at the postsynaptic membrane of the neuromuscular junction and bind acetylcholine molecules, allowing ions to move through the pore. Glutamate receptors are found in the postsynaptic membrane of cells in the central nervous system. The activity that is generated at the synapse by the binding of acetylcholine is terminated by acetylcholinesterase, an enzyme that rapidly hydrolyzes acetylcholine. AChRε, also known as CMS1D, CMS1E, CMS2A, FCCMS, SCCMS or CHRNE, is a 493 amino acid multi-pass membrane protein associated with congenital myasthenic syndrome slow-channel type (SCCMS), congenital myasthenic syndrome fast-channel type (FCCMS) and congenital myasthenic syndrome with acetylcholine receptor deficiency.

L'anticorps Nicotinic Acetylcholine Receptor epsilon/CHRNE préféré est l'Anticorps Nicotinic Acetylcholine Receptor epsilon/CHRNE (B-11): sc-376747.