Molecular structure of A 350619 hydrochloride, CAS Number: 538368-27-3
A 350619 hydrochloride (CAS 538368-27-3)
See product citations (1)
Alternate Names:
3-[2-[(4-Chlorophenyl)thiophenyl]-N-[4-(dimethylamino)butyl]-2-propenamide hydrochloride
Application:
A 350619 hydrochloride is an activator of soluble guanylyl cyclase
CAS Number:
538368-27-3
Molecular Weight:
425.41
Molecular Formula:
C21H25ClN2OS•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Activator of soluble guanylyl cyclase (sGC). Activates basal sGC and synergistically activates sGC in the presence of NO. Relaxes cavernosum smooth muscle in vitro and induces penile erections in rats in vivo.
A 350619 hydrochloride (CAS 538368-27-3) References
- A Rho-kinase inhibitor, soluble guanylate cyclase activator and nitric oxide-releasing PDE5 inhibitor: novel approaches to erectile dysfunction. | Cellek, S., et al. 2002. Expert Opin Investig Drugs. 11: 1563-73. PMID: 12437503
- A-350619: a novel activator of soluble guanylyl cyclase. | Miller, LN., et al. 2003. Life Sci. 72: 1015-25. PMID: 12495780
- Soluble guanylyl cyclase: physiological role as an NO receptor and the potential molecular target for therapeutic application. | Nakane, M. 2003. Clin Chem Lab Med. 41: 865-70. PMID: 12940510
- NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. | Evgenov, OV., et al. 2006. Nat Rev Drug Discov. 5: 755-68. PMID: 16955067
- Acrylamide analog as a novel nitric oxide-independent soluble guanylyl cyclase activator. | Nakane, M., et al. 2006. J Pharmacol Sci. 102: 231-8. PMID: 17050951
- Exploring the potential of NO-independent stimulators and activators of soluble guanylate cyclase for the medical treatment of erectile dysfunction. | Gur, S., et al. 2010. Curr Pharm Des. 16: 1619-33. PMID: 20201788
- ABCC5 supports osteoclast formation and promotes breast cancer metastasis to bone. | Mourskaia, AA., et al. 2012. Breast Cancer Res. 14: R149. PMID: 23174366
- Anodal iontophoresis of a soluble guanylate cyclase stimulator induces a sustained increase in skin blood flow in rats. | Kotzki, S., et al. 2013. J Pharmacol Exp Ther. 346: 424-31. PMID: 23838678
- Soluble guanylate cyclase stimulators in pulmonary hypertension. | Stasch, JP. and Evgenov, OV. 2013. Handb Exp Pharmacol. 218: 279-313. PMID: 24092345
- Redox regulation of soluble guanylyl cyclase. | Shah, RC., et al. 2018. Nitric Oxide. 76: 97-104. PMID: 29578056
- Soluble Guanylate Cyclase Stimulators and Activators: Where are We and Where to Go? | Xiao, S., et al. 2019. Mini Rev Med Chem. 19: 1544-1557. PMID: 31362687
- Cutaneous iontophoresis of vasoactive medications in patients with scleroderma-associated pulmonary arterial hypertension. | Al Abdi, S., et al. 2021. Microcirculation. e12734. PMID: 34741773
Activator of:
GCS.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A 350619 hydrochloride, 10 mg | sc-203787 | 10 mg | $179.00 | |||
A 350619 hydrochloride, 50 mg | sc-203787A | 50 mg | $756.00 |