Molecular structure of 8-Methoxymethyl-IBMX, CAS Number: 78033-08-6
8-Methoxymethyl-IBMX (CAS 78033-08-6)
See product citations (2)
Alternate Names:
8-Methoxymethyl-3-isobutyl-1-methylxanthine
Application:
8-Methoxymethyl-IBMX is a Cam-PDE selective inhibitor
CAS Number:
78033-08-6
Purity:
98%
Molecular Weight:
266.3
Molecular Formula:
C12H18N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
8-Methoxymethyl-IBMX has been reported to be a selective inhibitor of calmodulin-stimulated phosphodiesterase (Cam-PDE). By inhibiting Cam-PDE, 8-Methoxymethyl-IBMX causes an increase in cGMP but not in cAMP levels in 1-norepinephrine preincubated rabbit aortic slices. Experiments performed on catheterized rabbits with acute pulmonary hypertension show that the compound may cause a decrease in pulmonary artery pressure by causing vasodilation.
8-Methoxymethyl-IBMX (CAS 78033-08-6) References
- Inhibition of cGMP accumulation in mesangial cells by bradykinin and tyrosine kinase inhibitors. | Alric, C., et al. 1999. Int J Mol Med. 4: 557-64. PMID: 10534581
- The secretory response of the rat colon to the flavonol quercetin is dependent on Ca2+-calmodulin. | Cermak, R., et al. 2000. Exp Physiol. 85: 255-61. PMID: 10825411
- Response of rabbit ciliary process cyclic nucleotides to specific phosphodiesterase inhibitors. | Okada, K. and Gregory, DS. 2000. Curr Eye Res. 21: 774-81. PMID: 11120567
- Relationship between bicarbonate and cyclic nucleotide in the promoting effects on head-to-head agglutination in boar spermatozoa. | Harayama, H. and Kato, S. 2002. Asian J Androl. 4: 87-96. PMID: 12085098
- Effects of phosphodiesterase inhibitors on interleukin-4 and interleukin-13 generation from human basophils. | Eskandari, N., et al. 2004. Br J Pharmacol. 142: 1265-72. PMID: 15265810
- Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors. | Schermuly, RT., et al. 2005. Respir Res. 6: 76. PMID: 16033645
- In vivo effects of phosphodiesterase inhibition on basal cyclic guanosine monophosphate levels in the prefrontal cortex, hippocampus and cerebellum of freely moving rats. | Marte, A., et al. 2008. J Neurosci Res. 86: 3338-47. PMID: 18655195
- Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta. | Ahn, HS., et al. 1989. Biochem Pharmacol. 38: 3331-9. PMID: 2554921
- Estimating the magnitude of near-membrane PDE4 activity in living cells. | Xin, W., et al. 2015. Am J Physiol Cell Physiol. 309: C415-24. PMID: 26201952
- A low [Ca2+]i-induced enhancement of cAMP-activated ciliary beating by PDE1A inhibition in mouse airway cilia. | Kogiso, H., et al. 2017. Pflugers Arch. 469: 1215-1227. PMID: 28477148
- Effects of Extracts and Flavonoids from Drosera rotundifolia L. on Ciliary Beat Frequency and Murine Airway Smooth Muscle. | Hake, A., et al. 2022. Molecules. 27: PMID: 36235159
- Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1. | Yu, J., et al. 1997. Cell Signal. 9: 519-29. PMID: 9419816
Inhibitor of:
PDE, and PDE1A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-Methoxymethyl-IBMX, 10 mg | sc-201192 | 10 mg | $354.00 | |||
8-Methoxymethyl-IBMX, 50 mg | sc-201192A | 50 mg | $1173.00 |