Tetraspanins, including TSPAN18, are integral membrane proteins characterized by their four transmembrane domains. These proteins are involved in a wide variety of cellular processes, including cell development, activation, growth, and motility, largely due to their ability to associate with other proteins and form complex networks known as tetraspanin-enriched microdomains (TEMs). These domains serve as platforms for signal transduction, influencing the activities of associated proteins. Therefore, any molecule that could interact with TSPAN18 or associated proteins in a way that promotes these activities might be considered a potential "TSPAN18 Activator".
It's crucial to note that these activators would likely need to be able to interact with the cellular membrane in order to influence the function of TSPAN18, given its location within the membrane. Activators could potentially function through direct interaction with TSPAN18 or through indirect mechanisms, such as modifying the activity of proteins associated with TSPAN18 or altering the lipid environment of the membrane to influence TSPAN18 function. It's also possible that these activators could function via intracellular mechanisms, potentially influencing the transcription or translation of TSPAN18. In all cases, the end result would be an upregulation of the normal function of TSPAN18, potentially leading to enhanced cell development, activation, growth, or motility.
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| Nom du produit | CAS # | Ref. Catalogue | Quantité | Prix HT | CITATIONS | Classement |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Le PMA active la protéine kinase C, qui pourrait indirectement déclencher le TSPAN18 en contrôlant la fonction d'autres protéines par phosphorylation. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
En inhibant la synthèse des protéines, le cycloheximide pourrait indirectement permettre l'activation de TSPAN18. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
La dexaméthasone peut stimuler indirectement TSPAN18 en influençant une variété de processus cellulaires, y compris la réponse immunitaire, l'inflammation, et la croissance et la différenciation cellulaires. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
En inhibant mTOR, Rapamycin peut indirectement permettre l'activation de TSPAN18 en influençant la synthèse des protéines et la croissance cellulaire. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
La wortmannine inhibe les phosphoinositides 3-kinases (PI3K), ce qui peut indirectement déclencher l'action de TSPAN18 en affectant les voies de croissance et de prolifération cellulaires. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Le SB203580 inhibe la MAPK p38, ce qui pourrait indirectement stimuler l'activation de TSPAN18 en influençant la réponse cellulaire au stress et à l'inflammation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
La génistéine inhibe les tyrosines kinases, ce qui pourrait indirectement déclencher TSPAN18 en affectant de multiples voies de signalisation cellulaires. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Le LY294002 inhibe le PI3K, ce qui pourrait indirectement permettre l'activation de TSPAN18 en influençant la progression du cycle cellulaire et la croissance. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibe les c-Jun N-terminal kinases (JNK), ce qui pourrait indirectement permettre l'activation de TSPAN18 en influençant la réponse aux signaux de stress. | ||||||