SMG5 Activateurs
The class of compounds regarded as SMG5 activators comprises of chemicals capable of indirectly enhancing the functional capacity of SMG5, a critical component in the nonsense-mediated mRNA decay pathway (NMD). SMG5, pivotal for mRNA surveillance, ensures cellular integrity by targeting aberrant mRNA molecules for degradation. The activation of SMG5 can be modulated by chemicals that influence various molecular pathways intersecting with or parallel to the functional scope of SMG5. For example, chemicals which can modulate the phosphorylation states or stability of the mRNAs can have a profound effect on SMG5 activation. The regulation and stabilization of mRNA, and the intervention in its decay, can result in elevated levels of SMG5 activity due to the enhanced availability of its substrates, the aberrant mRNA molecules.
Chemicals that interfere with the upstream or downstream components of the NMD pathway can also be included in the category of SMG5 activators. The alteration in the levels and activity of the NMD components can indirectly lead to the activation of SMG5, influencing the overall efficiency and dynamics of the mRNA decay process.
VOIR ÉGALEMENT...
| Nom du produit | CAS # | Ref. Catalogue | Quantité | Prix HT | CITATIONS | Classement |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Active la Vimentine en stimulant la protéine kinase C (PKC), ce qui entraîne la phosphorylation de la Vimentine et la réorganisation du cytosquelette. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Inhibe les phosphatases, empêchant la déphosphorylation de la Vimentine et maintenant ainsi la Vimentine dans un état phosphorylé et actif. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Agit comme un inhibiteur de phosphatase, similaire à la caliculine A, en empêchant la déphosphorylation de la vimentine, ce qui entraîne une augmentation de la phosphorylation de la vimentine. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Augmente les niveaux intracellulaires d'AMPc, activant les protéines kinases qui peuvent phosphoryler la vimentine et favoriser son activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Induit un stress du réticulum endoplasmique (RE) et peut activer la protéine kinase C (PKC), entraînant la phosphorylation et l'activation de la vimentine. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Active diverses kinases, y compris les MAP kinases, qui peuvent phosphoryler la vimentine et conduire à son activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Fonctionne comme un ionophore calcique, augmentant les niveaux de calcium intracellulaire, ce qui peut activer les kinases dépendantes du calcium qui phosphorylent la Vimentine. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
La metformine active les récepteurs couplés aux protéines G, déclenchant des voies de signalisation en aval qui peuvent affecter l'organisation et l'activation de la vimentine. | ||||||