Pericentrin 1 Activateurs
The term Pericentrin 1 Activators refers to a broad class of chemicals that can indirectly influence the activity of Pericentrin 1 (PCNT), a protein integral to the function of centrosomes and the anchoring of microtubules. These chemicals exert their influence not by directly interacting with Pericentrin 1, but by modulating the cellular processes and pathways in which this protein plays a key role. Their impact on Pericentrin 1 activity is thus indirect, but nonetheless significant in the context of cellular function. Paclitaxel and Epothilone B are examples of such chemicals. They stabilize microtubules, preventing their disassembly. By maintaining the integrity of microtubules, these chemicals can indirectly affect the role of Pericentrin 1 in anchoring microtubules to the centrosome. On the other hand, chemicals such as Nocodazole, Vinblastine, Colchicine, and Combretastatin A4 disrupt microtubule polymerization. By altering the dynamics of microtubule assembly and disassembly, these chemicals can indirectly influence the function Pericentrin 1 serves in the centrosome cycle.
Inhibitors of Kinesin-5 (Eg5), Aurora kinases, PLK1, and CDK1 affect various aspects of the centrosome cycle, from centrosome maturation and separation to the entry into mitosis. Their influence on these processes can indirectly impact Pericentrin 1's function. The same can be said of Taxanes and Vincas, which respectively stabilize and disrupt microtubule dynamics, thereby influencing the dynamics of the centrosome cycle and indirectly the function of Pericentrin 1. In conclusion, the so-called Pericentrin 1 Activators are a diverse class of chemicals with the ability to indirectly affect the activity of Pericentrin 1. They do this by modulating the cellular processes that Pericentrin 1 is involved in, such as the centrosome cycle and the organization of microtubules. Despite the name, these chemicals are not direct activators of Pericentrin 1, but their influence on the cellular pathways and processes associated with this protein is what qualifies them as Pericentrin 1 Activators.
| Nom du produit | CAS # | Ref. Catalogue | Quantité | Prix HT | CITATIONS | Classement |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Le paclitaxel peut stabiliser les microtubules et empêcher leur désassemblage, affectant ainsi la dynamique du cycle du centrosome. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Le nocodazole peut perturber la polymérisation des microtubules, ce qui peut influencer le cycle du centrosome et affecter indirectement la fonction de la péricentrine 1. | ||||||
Vinblastine Sulfate | 143-67-9 | sc-201447 sc-201447A sc-201447B sc-201447C | 10 mg 50 mg 100 mg 1 g | $107.00 $404.00 $550.00 $2200.00 | 9 | |
La vinblastine peut inhiber la dynamique des microtubules, ce qui peut affecter le cycle du centrosome et influencer indirectement la fonction de la péricentrine 1. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
La colchicine peut perturber la polymérisation des microtubules et donc affecter le cycle du centrosome, influençant indirectement la fonction de la péricentrine 1. | ||||||
Epothilone A | 152044-53-6 | sc-207628 sc-207628A | 10 µg 1 mg | $210.00 $1000.00 | 1 | |
L'épothilone B peut stabiliser les microtubules, ce qui peut influencer le cycle du centrosome et affecter indirectement la fonction de la péricentrine 1. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $45.00 $79.00 | ||
La combrétastatine A4 peut perturber la fonction des microtubules, ce qui peut affecter le cycle du centrosome et influencer indirectement la fonction de la péricentrine 1. | ||||||