IL-1R8 Activateurs
Interleukin 1 Receptor 8 (IL-1R8), also known as Single Ig IL-1-Related Receptor (SIGIRR) or TIR8, is a protein that in humans is encoded by the IL1R8 gene. As part of the interleukin-1 receptor family, IL-1R8 plays a critical role in modulating immune response and inflammation.Unlike other members of the family, IL-1R8 does not actively participate in signal transduction for inflammatory responses. Instead, it acts as a "check" or negative regulator on the immune system. It does this by interfering with the signaling pathways of other, pro-inflammatory members of the interleukin-1 receptor family and Toll-like receptors. By blocking these pathways, IL-1R8 helps to inhibit excessive or chronic inflammation, which can lead to tissue damage and various diseases.
IL-1R8 is expressed in a variety of tissues, including immune cells and epithelial cells, reflecting its broad role in immune regulation. Dysregulation or mutations of IL-1R8 can contribute to an overactive immune response, potentially leading to autoimmune diseases or chronic inflammatory conditions. Conversely, it might also be implicated in immune evasion strategies by tumors.Research has shown that IL-1R8 is a potent modulator of immune response in conditions like sepsis, lung inflammation, and colitis, and it has been suggested as a potential target for these and other inflammatory diseases.
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| Nom du produit | CAS # | Ref. Catalogue | Quantité | Prix HT | CITATIONS | Classement |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Le resvératrol peut moduler les réponses immunitaires et pourrait indirectement affecter la signalisation de l'IL-1R8. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
La curcumine est connue pour ses propriétés anti-inflammatoires et pourrait indirectement influencer l'activité de l'IL-1R8. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
La vitamine D3 module la fonction immunitaire et pourrait avoir un effet indirect sur l'IL-1R8. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
L'EGCG affecte les voies de signalisation immunitaires et pourrait moduler indirectement l'IL-1R8. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Le sulforaphane, connu pour ses effets anti-inflammatoires, pourrait influencer IL-1R8. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
La quercétine module l'inflammation et les réponses immunitaires, en affectant potentiellement l'IL-1R8. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $41.00 | 4 | |
L'aspirine, par ses effets anti-inflammatoires, peut avoir un impact indirect sur IL-1R8. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Un flavonoïde qui module les voies inflammatoires, affectant probablement IL-1R8. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
La lutéoline a des propriétés anti-inflammatoires, qui pourraient affecter indirectement l'IL-1R8. | ||||||