Histone cluster 1 H2BD Activateurs
Histone H2B type D activators, in this context, refer to a group of chemicals that indirectly influence the functionality of Histone H2B type D, primarily through their effects on histone post-translational modifications (PTMs) and chromatin remodeling. These activators do not directly target Histone H2B type D but modulate the epigenetic landscape in which this histone operates.
The first category of activators includes histone deacetylase inhibitors like Trichostatin A, Sodium Butyrate, Vorinostat, and Valproic Acid. These compounds increase acetylation levels on histones, including H2B, by inhibiting the enzymes responsible for removing acetyl groups. Enhanced acetylation generally leads to a more open chromatin structure, facilitating transcriptional activation.
Another group consists of compounds like Anacardic Acid and Curcumin, which impact histone acetyltransferases and deacetylases, enzymes responsible for adding and removing acetyl groups, respectively. This modulation of enzyme activity can significantly impact the acetylation patterns on histones, including H2B.
DNA methyltransferase inhibitors like 5-Azacytidine and RG108 also play a role in modulating histone functionality. These inhibitors alter the methylation pattern of DNA, which can indirectly influence histone modifications and chromatin structure, thereby affecting the activity of Histone H2B type D.
In summary, Histone H2B type D activators encompass a range of chemicals that indirectly modulate the activity or functionality of Histone H2B type D through their effects on histone PTMs and chromatin remodeling. Understanding these interactions provides insights into the regulation of gene expression and the potential modulation of Histone H2B type D's role in chromatin dynamics.
VOIR ÉGALEMENT...
| Nom du produit | CAS # | Ref. Catalogue | Quantité | Prix HT | CITATIONS | Classement |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
La trichostatine A est un inhibiteur de l'histone désacétylase, qui affecte indirectement les niveaux d'acétylation des histones, y compris ceux de H2B. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Le butyrate de sodium agit comme un inhibiteur de l'histone désacétylase, influençant potentiellement l'acétylation de H2B et la structure de la chromatine. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Le vorinostat est un autre inhibiteur de l'histone désacétylase, qui affecte les schémas d'acétylation pouvant inclure l'histone H2B. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
L'acide valproïque, un acide gras à chaîne courte, est un inhibiteur de l'histone désacétylase, qui pourrait affecter l'acétylation de H2B. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
L'acide anacardique inhibe l'histone acétyltransférase, ce qui peut avoir un impact sur l'acétylation des histones, y compris H2B. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
La caféine peut influencer diverses voies de signalisation et il a été démontré qu'elle affecte indirectement la modification des histones. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
La 5-azacytidine, un inhibiteur de l'ADN méthyltransférase, peut altérer la structure de la chromatine, en affectant indirectement les modifications des histones. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $178.00 $367.00 | 7 | |
Methylstat est un inhibiteur de protéines contenant le domaine Jumonji, ayant un impact potentiel sur la méthylation des histones, y compris H2B. | ||||||
Inhibiteur Histone Lysine Methyltransferase Inhibitor | 935693-62-2 free base | sc-202651 | 5 mg | $148.00 | 4 | |
BIX-01294 est un inhibiteur de l'histone méthyltransférase G9a, qui peut influencer les schémas de méthylation des histones. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 est un inhibiteur de l'ADN méthyltransférase, ce qui peut modifier indirectement la structure de la chromatine et la modification des histones. | ||||||