Date published: 2025-9-9

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Inhibiteurs GP78-1

GP78-1 inhibitors represent a specific chemical class of compounds designed to target the protein GP78-1, also known as RNF45. GP78-1 is an E3 ubiquitin ligase responsible for regulating protein quality control and degradation processes within the cell. Inhibiting GP78-1 activity is an area of active research to gain insights into the molecular pathways that govern protein degradation. These inhibitors are meticulously developed to interact with GP78-1 at a molecular level, with the aim of modulating its enzymatic function. By specifically disrupting GP78-1's activity, researchers seek to elucidate its role in cellular protein homeostasis and degradation.

The chemical structures of GP78-1 inhibitors can vary, and they are designed to interact with specific binding sites or domains of GP78-1, thus interfering with its ability to tag proteins for degradation. Investigating GP78-1 inhibitors is an essential endeavor to advance our understanding of the complex cellular mechanisms that govern protein turnover and ensure cellular integrity. Such research contributes to the broader knowledge of cellular processes and their regulation, with implications for various biological and disease-related contexts.

VOIR ÉGALEMENT...

Nom du produitCAS #Ref. CatalogueQuantitéPrix HTCITATIONS Classement

Eeyarestatin I

412960-54-4sc-358130B
sc-358130
sc-358130A
sc-358130C
sc-358130D
sc-358130E
5 mg
10 mg
25 mg
50 mg
100 mg
500 mg
$112.00
$199.00
$347.00
$683.00
$1336.00
$5722.00
12
(1)

Ce composé inhibe l'ERAD en interférant avec p97/VCP, un composant clé de la voie dans laquelle GP78 est impliqué.

Stat3 Inhibitor VI, S3I-201

501919-59-1sc-204304
10 mg
$148.00
104
(1)

Cet inhibiteur de l'UBE2N peut perturber l'activité de conjugaison de l'ubiquitine, affectant indirectement la fonction de GP78.

Clotrimazole

23593-75-1sc-3583
sc-3583A
100 mg
1 g
$41.00
$56.00
6
(2)

Connu comme un inhibiteur de l'ATPase p97/VCP, le Clotrimazole pourrait influencer les processus ERAD médiés par GP78.

DBeQ

177355-84-9sc-499943
10 mg
$330.00
1
(0)

DBeQ est un inhibiteur sélectif de p97/VCP, ce qui pourrait avoir un impact sur la voie ERAD où opère le GP78.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$132.00
$1064.00
115
(2)

Un inhibiteur du protéasome qui pourrait affecter les processus en aval de l'activité ubiquitine ligase de GP78.

NMS-873

1418013-75-8sc-478803
5 mg
$300.00
(0)

Le NMS-873, un puissant inhibiteur de p97/VCP, pourrait indirectement affecter la fonction de GP78 dans l'ERAD.

Lactacystin

133343-34-7sc-3575
sc-3575A
200 µg
1 mg
$165.00
$575.00
60
(2)

Inhibiteur du protéasome, affectant la voie ubiquitine-protéasome, influençant ainsi indirectement GP78.

Carfilzomib

868540-17-4sc-396755
5 mg
$40.00
(0)

Un autre inhibiteur du protéasome, ayant un impact potentiel sur la voie impliquant GP78.