ADAMTS-10 Activateurs
ADAMTS-10 (A Disintegrin And Metalloproteinase with Thrombospondin Motifs 10) is a member of the ADAMTS family of extracellular proteases, characterized by their zinc-dependent metalloproteinase and thrombospondin type 1 motif domains. ADAMTS-10 is primarily expressed in various tissues during embryonic development and plays crucial roles in extracellular matrix (ECM) remodeling, tissue morphogenesis, and cell migration. Functionally, ADAMTS-10 contributes to tissue homeostasis by regulating the turnover and organization of ECM components, including proteoglycans, collagen, and elastin. Its proteolytic activity enables the cleavage of ECM proteins, leading to structural modifications that influence cell behavior and tissue architecture. Additionally, ADAMTS-10 has been implicated in diverse physiological processes such as angiogenesis, wound healing, and skeletal development, highlighting its significance in both normal development and pathological conditions.
Activation of ADAMTS-10 is regulated by various mechanisms that control its enzymatic activity and substrate specificity. Post-translational modifications, such as glycosylation and proteolytic processing, can modulate ADAMTS-10 activity by affecting its stability, localization, and interaction with ECM substrates. Furthermore, interactions with other proteins and signaling molecules within the ECM microenvironment can regulate ADAMTS-10 function. For instance, binding of ECM proteins or cell surface receptors can induce conformational changes in ADAMTS-10, facilitating its activation and substrate recognition. Additionally, signaling pathways such as the MAPK/ERK pathway and the TGF-β signaling cascade have been implicated in the regulation of ADAMTS-10 expression and activity. Activation of these pathways can modulate ADAMTS-10 transcription, translation, or post-translational modifications, thereby influencing its proteolytic function and biological activity. Overall, the multifaceted regulation of ADAMTS-10 activation underscores its importance in ECM dynamics and tissue homeostasis, with implications for various physiological and pathological processes.
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| Nom du produit | CAS # | Ref. Catalogue | Quantité | Prix HT | CITATIONS | Classement |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
Les inhibiteurs du TGF-β comme le SB431542 peuvent activer indirectement l'ADAMTS-10 en empêchant sa régulation négative, car la signalisation du TGF-β supprime généralement l'expression de l'ADAMTS-10. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Les inhibiteurs d'HDAC comme le vorinostat peuvent potentiellement activer l'ADAMTS-10 en modulant la régulation épigénétique, ce qui entraîne une augmentation de l'expression des gènes, y compris celle de l'ADAMTS-10. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Les composés inhibant la synthèse du collagène, comme l'acide ascorbique, peuvent indirectement activer l'ADAMTS-10 en réduisant la disponibilité des substrats du collagène, ce qui a un impact sur son activité. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $75.00 $265.00 | 55 | |
Les inhibiteurs de MMP comme le GM6001 peuvent indirectement activer l'ADAMTS-10 en empêchant la dégradation des composants de la MEC, ce qui maintient les substrats disponibles pour l'action de l'ADAMTS-10. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Les activateurs Nrf2 comme le sulforaphane peuvent potentiellement activer l'ADAMTS-10 en renforçant la réponse antioxydante cellulaire, ce qui peut affecter l'activité de l'ADAMTS-10 en cas de stress oxydatif. | ||||||
Dimethyloxaloylglycine (DMOG) | 89464-63-1 | sc-200755 sc-200755A sc-200755B sc-200755C | 10 mg 50 mg 100 mg 500 mg | $82.00 $295.00 $367.00 $764.00 | 25 | |
Les inhibiteurs d'hydroxylase comme la diméthyloxalylglycine peuvent potentiellement activer l'ADAMTS-10 en modulant les modifications post-traductionnelles et en influençant sa stabilité ou son activité. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
Les piégeurs de ROS comme la N-acétylcystéine peuvent indirectement activer l'ADAMTS-10 en réduisant le stress oxydatif, ce qui peut avoir un impact sur son activité dans les environnements extracellulaires oxydatifs. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
Les modulateurs de la signalisation Notch comme le DAPT peuvent potentiellement avoir un impact sur l'ADAMTS-10 en modifiant les voies de communication cellule-cellule, ce qui peut influencer son expression ou son activité. | ||||||