Molecular structure of Z-VAD(OMe)-FMK, CAS Number: 187389-52-2
Z-VAD(OMe)-FMK (CAS 187389-52-2)
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Alternate Names:
Z-VAD(OMe)-FMK also known as Z-VAD-FMK; pan-Caspase Inhibitor; Caspase family inhibitor (fluoromethylketone); Z-Val-Ala-Asp(OMe)-fluoromethylketone; Z-VAD(OMe)-fluoromethylketone, Caspase Inhibitor (FMK); Z-Val-Ala-Asp fluoromethyl ketone
Application:
Z-VAD(OMe)-FMK is an irreversible and cell permeable broad-spectrum Caspase Inhibitor that has shown to inhibit caspase-1 and caspase-3
CAS Number:
187389-52-2
Purity:
≥95%
Molecular Weight:
467.49
Molecular Formula:
C22H30FN3O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Z-VAD(OMe)-FMK is an irreversible and cell permeable broad-spectrum Caspase Inhibitor displaying an IC50 of 5.8 nM in HepG2 cells. Z-VAD(OMe)-FMK may act to inhibit caspase-1 and caspase-3. Z-VAD(OMe)-FMK also been shown to inhibit Fas-mediated apoptosis in Jurkat T cells and apoptosis in THP.1 cells induced by diverse stimuli (including cycloheximide, thapsigargin, etoposide and staurosporine). Furthermore, anti-CD95-induced hepatocyte apoptosis was prevented in a concentration-dependent manner by inhibitor Z-VAD-FMK (IC50 = 1.5 nM). Additionally, Z-VAD(OMe)-FMK has been shown that pretreatment of MDA-MB-231 and HL-60 cells with Z-VAD(OMe)-FMK also inhibits apoptosis.
Z-VAD(OMe)-FMK (CAS 187389-52-2) References
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Inhibitor of:
Apoptosis, caspase-1, caspase-3, and Chemical and Peptide Caspase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Z-VAD(OMe)-FMK, 1 mg | sc-311561 | 1 mg | $168.00 | |||
Z-VAD(OMe)-FMK, 5 mg | sc-311561A | 5 mg | $625.00 | |||
Z-VAD(OMe)-FMK, 10 mg | sc-311561B | 10 mg | $1100.00 |