Date published: 2026-6-16

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Z-VAD-FMK (CAS 187389-52-2)

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Application:
Z-VAD-FMK is Irreversible, cell-permeable, broad-spectrum caspase Inhibitor
CAS Number:
187389-52-2
Purity:
≥95%
Molecular Weight:
467.49
Molecular Formula:
C22H30FN3O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Z-VAD-FMK is an irreversible, cell-permeable, broad-spectrum caspase inhibitor. Z-VAD-FMK limited Fas-induced mouse liver damage and apoptosis to


Z-VAD-FMK (CAS 187389-52-2) References

  1. Monocytic cell necrosis is mediated by potassium depletion and caspase-like proteases.  |  Warny, M. and Kelly, CP. 1999. Am J Physiol. 276: C717-24. PMID: 10070000
  2. TNF-induced enterocyte apoptosis and detachment in mice: induction of caspases and prevention by a caspase inhibitor, ZVAD-fmk.  |  Piguet, PF., et al. 1999. Lab Invest. 79: 495-500. PMID: 10212002
  3. Correlation of tumor necrosis factor alpha (TNF alpha) with high Caspase 3-like activity in myelodysplastic syndromes.  |  Mundle, SD., et al. 1999. Cancer Lett. 140: 201-7. PMID: 10403560
  4. A specific inhibitor of apoptosis decreases tissue injury after intestinal ischemia-reperfusion in mice.  |  Farber, A., et al. 1999. J Vasc Surg. 30: 752-60. PMID: 10514215
  5. Protective effect of a caspase inhibitor in models for cerebral ischemia in vitro and in vivo.  |  Wiessner, C., et al. 2000. Cell Mol Biol (Noisy-le-grand). 46: 53-62. PMID: 10726971
  6. Apoptosis in Alzheimer's disease--an update.  |  Shimohama, S. 2000. Apoptosis. 5: 9-16. PMID: 11227497
  7. Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons.  |  Barsoum, MJ., et al. 2006. EMBO J. 25: 3900-11. PMID: 16874299
  8. GDC-0152-induced autophagy promotes apoptosis in HL-60 cells.  |  Peiqi, L., et al. 2018. Mol Cell Biochem. 445: 135-143. PMID: 29299747
  9. Involvement of multiple proteases during Fas-mediated apoptosis in T lymphocytes.  |  Chow, SC., et al. 1995. FEBS Lett. 364: 134-8. PMID: 7538469
  10. An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells.  |  Zhu, H., et al. 1995. FEBS Lett. 374: 303-8. PMID: 7589559
  11. Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32.  |  Slee, EA., et al. 1996. Biochem J. 315 (Pt 1): 21-4. PMID: 8670109
  12. Activation of PKCalpha downstream from caspases during apoptosis induced by 7-hydroxystaurosporine or the topoisomerase inhibitors, camptothecin and etoposide, in human myeloid leukemia HL60 cells.  |  Shao, RG., et al. 1997. J Biol Chem. 272: 31321-5. PMID: 9395460
  13. Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver.  |  Chandler, JM., et al. 1998. J Biol Chem. 273: 10815-8. PMID: 9556551

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Z-VAD-FMK, 500 µg

sc-3067
500 µg
$75.00