UCH-L3 para análisis funcionales de las repuestas celulares a UCH-L
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UCH-L3 Antibody (ZE-17) is a high quality monoclonal UCH-L3 antibody (also designated UCH-L3 antibody) suitable for the detection of the UCH-L3 protein of mouse, rat and human origin. UCH-L3 Antibody (ZE-17) is available as the non-conjugated anti-UCH-L3 antibody. UCH-L1 (ubiquitin C-terminal hydrolase) is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCH-L1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. UCH-L1 is expressed in brain neurons. Examination of specific brain regions reveals expression in all areas tested, particularly in the substantia nigra. UCH-L1 represents 1 to 2% of total soluble brain protein. Its occurrence in Lewy bodies and its function in the proteasome pathway make it a compelling candidate gene in Parkinson disease. The gene which encodes UCH-L1 maps to human chromosome 4p14. The 230 amino acid human UCH-L3 protein is 54% identical to that of UCH-L1. UCH-L3 is the predominant thiol protease and has high-affinity binding sites for ubiquitin.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.