TR2 Antibody (G-11): sc-365729

TR2 Antibody (G-11) is a mouse monoclonal IgG3 antibody that detects TR2 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TR2, an orphan receptor belonging to the steroid/thyroid hormone receptor superfamily, plays a crucial role in regulating various biological processes, including growth, differentiation, and development. TR2 is primarily located in the nucleus, where anti-TR2 antibody (G-11) can detect binding to specific regulatory elements of genes such as erythropoietin, muscle-specific aldolase A, and CNTF-15, thereby influencing gene expression and cellular function. Nuclear localization of TR2 allows direct interaction with DNA and modulates transcriptional activity, which is essential for proper cellular responses to hormonal signals. Additionally, TR2 forms heterodimers with TR4, which is implicated in neurogenesis and germ cell development, further underscoring TR2′s importance in developmental biology. TR2 expression is downregulated by p53 and ionizing radiation, suggesting a potential role in linking stress responses to steroid receptor signaling pathways. With diverse functions and critical regulatory roles, TR2 is a significant target for research in developmental and cancer biology, making TR2 (G-11) monoclonal antibody an invaluable tool for scientists studying these processes.

The preferred TR2 antibody is TR2 Antibody (D-4): sc-374049.