Molecular structure of TPEN, CAS Number: 16858-02-9
TPEN (CAS 16858-02-9)
See product citations (10)
Alternate Names:
N,N,N′,N′-tetrakis(2-pyridylmethyl)ethane-1,2-diamine
Application:
TPEN is an apoptosis inducer and heavy metal chelator
CAS Number:
16858-02-9
Purity:
≥97%
Molecular Weight:
424.54
Molecular Formula:
C26H28N6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
TPEN is a high-affinity chelator for heavy metal ions, with a particular affinity for zinc, and is widely used in research to create states of metal ion deficiency. In cellular and molecular biology studies, TPEN is employed to deplete available zinc and investigate the role of this metal in various biological processes, such as enzyme function, protein folding, and gene expression. It is instrumental in the study of zinc signaling pathways and the elucidation of the metal′s impact on cellular homeostasis. Additionally, TPEN is utilized in research focusing on the cellular and physiological consequences of metal ion imbalance, which is relevant to understanding the mechanisms of certain neurodegenerative conditions and metal toxicity. The chelating properties of TPEN also make it a useful tool for studying the interactions between metal ions and proteins or other biomolecules.
TPEN (CAS 16858-02-9) References
- Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release. | Aizenman, E., et al. 2000. J Neurochem. 75: 1878-88. PMID: 11032877
- Role of cellular zinc in programmed cell death: temporal relationship between zinc depletion, activation of caspases, and cleavage of Sp family transcription factors. | Chimienti, F., et al. 2001. Biochem Pharmacol. 62: 51-62. PMID: 11377396
- Mechanism of apoptosis induced by zinc deficiency in peripheral blood T lymphocytes. | Kolenko, VM., et al. 2001. Apoptosis. 6: 419-29. PMID: 11595831
- New example of a non-heme mononuclear iron(IV) oxo complex. Spectroscopic data and oxidation activity. | Martinho, M., et al. 2005. Inorg Chem. 44: 9592-6. PMID: 16323949
- Effect of TPEN on the calcium release of cultured C2C12 mouse myotubes. | Sztretye, M., et al. 2007. J Muscle Res Cell Motil. 28: 421-8. PMID: 18365758
- Validation of TPEN as a zinc chelator in fluorescence probing of calcium in cells with the indicator Fura-2. | Matias, CM., et al. 2010. J Fluoresc. 20: 377-80. PMID: 19821015
- Acidosis-induced zinc-dependent death of cultured cerebellar granule neurons. | Isaev, NK., et al. 2010. Cell Mol Neurobiol. 30: 877-83. PMID: 20373017
- Inhibitory potential of three zinc chelating agents against the proteolytic, hemorrhagic, and myotoxic activities of Echis carinatus venom. | Nanjaraj Urs, AN., et al. 2015. Toxicon. 93: 68-78. PMID: 25447774
- Progressive Hemorrhage and Myotoxicity Induced by Echis carinatus Venom in Murine Model: Neutralization by Inhibitor Cocktail of N,N,N',N'-Tetrakis (2-Pyridylmethyl) Ethane-1,2-Diamine and Silymarin. | Nanjaraj Urs, AN., et al. 2015. PLoS One. 10: e0135843. PMID: 26274501
- Newport Green, a fluorescent sensor of weakly bound cellular Zn(2+): competition with proteome for Zn(2). | Karim, MR. and Petering, DH. 2016. Metallomics. 8: 201-10. PMID: 26694316
- Reduced metallothionein expression induced by Zinc deficiency results in apoptosis in hepatic stellate cell line LX-2. | Kang, M., et al. 2015. Int J Clin Exp Med. 8: 20603-9. PMID: 26884979
- Effects of Zinc Chelators on Aflatoxin Production in Aspergillus parasiticus. | Wee, J., et al. 2016. Toxins (Basel). 8: PMID: 27271668
- Administration of Zinc Chelators Improves Survival of Mice Infected with Aspergillus fumigatus both in Monotherapy and in Combination with Caspofungin. | Laskaris, P., et al. 2016. Antimicrob Agents Chemother. 60: 5631-9. PMID: 27401578
- In Vitro Activity of Combinations of Zinc Chelators with Amphotericin B and Posaconazole against Six Mucorales Species. | Leonardelli, F., et al. 2019. Antimicrob Agents Chemother. 63: PMID: 30885898
- Apoptosis is dependent on intracellular zinc and independent of intracellular calcium in lymphocytes. | Treves, S., et al. 1994. Exp Cell Res. 211: 339-43. PMID: 8143781
Inhibitor of:
2810408P10Rik, 4930432O21Rik, 5730403M16Rik, ALS2CR16, APOBEC3F, AU017455, C2orf53, Calgranulin B, IscU1, IscU2, melanopsin, Metal ABC transporter substrate-binding lipoprotein, MTF-1, Protein tyrosine phosphatase (PRL1, PRL2 ,PRL3) inhibitors, SLC30, SLC39A11, TMC8, VAT1L, YDJC, ZBTB25, ZCCHC12, ZCCHC2, ZFOC1, ZFP1, ZFP2, ZFP64, Zfp799, Zfp871, ZIP1, ZIP10, ZIP14, ZIP2, ZIP3, ZIP5, ZIP7, ZIP9, ZMAT1, ZNF16, ZNF191, ZNF202, ZNF256, ZNF336, ZNF430, ZNF552, ZNF555, ZNF589, ZNF598, ZNF662, ZNF688, ZNF696, ZNF7, ZNF707, ZNF74, ZNF764, ZNF852, ZnT-5, ZnT-7, ZnT-8, and ZSWIM1.Activator of:
Enigma, fzr, IZUMO2, SLC39A12, SLC39A13, YadA, ZCCHC18, Zfp738, ZFP772, ZIM1, ZIP1, ZNF583, ZNF740, ZnT-1, and ZnT-4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TPEN, 100 mg | sc-200131 | 100 mg | $130.00 |