Molecular structure of Tizanidine • HCl, CAS Number: 64461-82-1
Tizanidine • HCl (CAS 64461-82-1)
Alternate Names:
5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride; Tizanidine hydrochloride
Application:
Tizanidine • HCl is a centrally acting α2-adrenergic (α2-AR) agonist
CAS Number:
64461-82-1
Molecular Weight:
290.2
Molecular Formula:
C9H8ClN5S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tizanidine • HCl is a compound utilized in research focused on the central nervous system. It acts principally as an α2 adrenergic receptor agonist, and its use in studies allows for the examination of neurotransmitter inhibition and the modulation of synaptic transmission. The research interest in Tizanidine • HCl lies in its ability to elucidate the pathways involved in the inhibition of motor neurons, which is essential for understanding muscle spasticity mechanisms. Additionally, Tizanidine HCl is used to investigate its effects on nociceptive pathways and pain perception, providing insights into the modulation of sensory neuron activity.
Tizanidine • HCl (CAS 64461-82-1) References
- Systemic tizanidine hydrochloride (Zanaflex) partially decreases experimental postoperative pain in rats. | Hord, AH., et al. 2001. Anesth Analg. 93: 1307-9, table of contents. PMID: 11682420
- Systemic tizanidine hydrochloride (Zanaflex) relieves thermal hyperalgesia in rats with an experimental mononeuropathy. | Hord, AH., et al. 2001. Anesth Analg. 93: 1310-5. PMID: 11682421
- Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain. | Kawamata, T., et al. 2003. Anesthesiology. 98: 1480-3. PMID: 12766661
- Effect of intrathecal tizanidine on antinociception and blood pressure in the rat. | McCarthy, RJ., et al. 1990. Pain. 40: 333-338. PMID: 2326097
- Chitosan lactate wafer as a platform for the buccal delivery of tizanidine HCl: in vitro and in vivo performance. | El-Mahrouk, GM., et al. 2014. Int J Pharm. 467: 100-12. PMID: 24680961
- Effects of tizanidine, eperisone and afloqualone on feline dorsal horn neuronal responses to peripheral cutaneous noxious and innocuous stimuli. | Davies, J. 1989. Neuropharmacology. 28: 1357-62. PMID: 2615916
- A UHPLC-UV Method to Quantify Skin Deposition and Transdermal Permeation of Tizanidine Hydrochloride. | del Río-Sancho, S., et al. 2016. J Chromatogr Sci. 54: 790-5. PMID: 26892401
- Development of Tizanidine HCl-Meloxicam loaded mucoadhesive buccal films: In-vitro and in-vivo evaluation. | Zaman, M., et al. 2018. PLoS One. 13: e0194410. PMID: 29566073
- Evaluation of bilosomes as nanocarriers for transdermal delivery of tizanidine hydrochloride: in vitro and ex vivo optimization. | Khalil, RM., et al. 2019. J Liposome Res. 29: 171-182. PMID: 30221568
- Tizanidine (Hydrochloride) Inhibits A549 Lung Cancer Cell Proliferation and Motility Through Regulating Nischarin. | Zhao, L., et al. 2020. Onco Targets Ther. 13: 291-298. PMID: 32021275
- Formulation development and optimization studies of mouth dissolving tablets of tizanidine HCl. | Iqbal, H., et al. 2020. Pak J Pharm Sci. 33: 245-251. PMID: 32122855
- [Scientific-medical heritage of physician-revolutionary V. N. Chepalov]. | Starikov, NM. and Bova, PA. 1976. Sov Zdravookhr. 66-9. PMID: 797001
- Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes. | Piletz, JE., et al. 1996. J Pharmacol Exp Ther. 279: 694-702. PMID: 8930173
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AR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tizanidine • HCl, 100 mg | sc-200148 | 100 mg | $63.00 | |||
Tizanidine • HCl, 500 mg | sc-200148A | 500 mg | $257.00 |