Molecular structure of TIC10
TIC10 (CAS 41276-02-2)
Application:
TIC10 is a small molecule that induces TRAIL in a p53-independent manner
CAS Number:
41276-02-2
Molecular Weight:
386.49
Molecular Formula:
C24H26N4O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
TIC10 (TRAIL-inducing compound 10) is an orally active, stable and potent small molecule that has been shown to transcriptionally induce TRAIL and TRAIL-mediated cell death in a p53-independent manner. TIC10 also activates the gene Foxo3a by dually inactivating Akt and ERK. TIC10 crosses the blood-brain barrier and is expected to be useful as an antitumor therapeutic agent.
TIC10 (CAS 41276-02-2) References
J.E. Allen et al. Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects. Sci. Transl. Med. 2013, 5, 171ra17.J.E. Allen. Efficacy and mechanistic evaluation of TIC10, a novel antitumor agent. Dissertation Univ. Pennsylvania 2012.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TIC10, 10 mg | sc-394486 | 10 mg | $330.00 |