Thrombospondin 3 Antibody (A-12): sc-25348
- Thrombospondin 3 Antibody (A-12) is a mouse monoclonal IgG2a κ Thrombospondin 3 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 131-280 of Thrombospondin 3 of human origin
- Thrombospondin 3 Antibody (A-12) is recommended for detection of thrombospondin 3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Thrombospondin 3 Antibody (A-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Thrombospondin 3 Antibody (A-12) for WB and IHC(P) applications. These reagents are now offered in bundles with Thrombospondin 3 Antibody (A-12) (see ordering information below).
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Thrombospondin 3 Antibody (A-12) is a mouse monoclonal IgG2a kappa light chain antibody that detects Thrombospondin 3 (THBS3) of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Thrombospondin 3 antibody (A-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. THBS3 is a member of the thrombospondin family of glycoproteins, which are crucial for cell-to-cell and cell-to-matrix signaling. THBS3 is primarily located in the extracellular matrix, where THBS3 plays a significant role in regulating cell adhesion, migration, and proliferation. The extracellular matrix is vital for maintaining tissue architecture and facilitating communication between cells, making THBS3 essential for developmental processes and tissue repair. THBS3 interacts with various proteins, including integrins and growth factors, which further underscores THBS3′s importance in modulating cellular responses and influencing the behavior of surrounding cells. THBS3′s ability to bind heparin and other extracellular matrix components highlights THBS3′s role in mediating complex biological interactions, making THBS3 a valuable target for research in developmental biology and regenerative medicine.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Thrombospondin 3 Antibody (A-12) References:
- Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers. | O'Rourke, KM., et al. 1992. J Biol Chem. 267: 24921-4. PMID: 1459996
- Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans. | LaBell, TL., et al. 1992. Genomics. 12: 421-9. PMID: 1559694
- Physiology of thrombospondin. | Mosher, DF. 1990. Annu Rev Med. 41: 85-97. PMID: 1691903
- A second, expressed thrombospondin gene (Thbs2) exists in the mouse genome. | Bornstein, P., et al. 1991. J Biol Chem. 266: 12821-4. PMID: 1712771
- Thrombospondin-4, an extracellular matrix protein expressed in the developing and adult nervous system promotes neurite outgrowth. | Arber, S. and Caroni, P. 1995. J Cell Biol. 131: 1083-94. PMID: 7490284
- Thrombospondin 3 is a pentameric molecule held together by interchain disulfide linkage involving two cysteine residues. | Qabar, A., et al. 1995. J Biol Chem. 270: 12725-9. PMID: 7759526
- The functions of thrombospondin and its involvement in physiology and pathophysiology. | Lahav, J. 1993. Biochim Biophys Acta. 1182: 1-14. PMID: 8347680
- Thrombospondin-1. | Adams, JC. 1997. Int J Biochem Cell Biol. 29: 861-5. PMID: 9304800
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thrombospondin 3 Antibody (A-12) | sc-25348 | 200 µg/ml | $322.00 | |||
Thrombospondin 3 Antibody (A-12): m-IgG Fc BP-HRP Bundle | sc-525518 | 200 µg Ab; 10 µg BP | $361.00 | |||
Thrombospondin 3 Antibody (A-12): m-IgG2a BP-HRP Bundle | sc-546301 | 200 µg Ab; 10 µg BP | $361.00 | |||
Thrombospondin 3 Antibody (A-12) AC | sc-25348 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Thrombospondin 3 Antibody (A-12) HRP | sc-25348 HRP | 200 µg/ml | $322.00 | |||
Thrombospondin 3 Antibody (A-12) FITC | sc-25348 FITC | 200 µg/ml | $336.00 | |||
Thrombospondin 3 Antibody (A-12) PE | sc-25348 PE | 200 µg/ml | $349.00 | |||
Thrombospondin 3 Antibody (A-12) Alexa Fluor® 488 | sc-25348 AF488 | 200 µg/ml | $364.00 | |||
Thrombospondin 3 Antibody (A-12) Alexa Fluor® 546 | sc-25348 AF546 | 200 µg/ml | $364.00 | |||
Thrombospondin 3 Antibody (A-12) Alexa Fluor® 594 | sc-25348 AF594 | 200 µg/ml | $364.00 | |||
Thrombospondin 3 Antibody (A-12) Alexa Fluor® 647 | sc-25348 AF647 | 200 µg/ml | $364.00 | |||
Thrombospondin 3 Antibody (A-12) Alexa Fluor® 680 | sc-25348 AF680 | 200 µg/ml | $364.00 | |||
Thrombospondin 3 Antibody (A-12) Alexa Fluor® 790 | sc-25348 AF790 | 200 µg/ml | $364.00 |