TFIIH p52 Antibody (A-2): sc-271742
- TFIIH p52 Antibody (A-2) is a mouse monoclonal IgA κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 431-462 at the C-terminus of TFIIH p52 of human origin
- recommended for detection of TFIIH p52 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and canine and porcine
- TransCruz reagent for ChIP application (sc-271742 X, 200 µg/0.1 ml)
- m-IgGκ BP-HRP is the preferred secondary detection reagent for TFIIH p52 Antibody (A-2) for WB and IHC(P) applications. This reagent is now offered in a bundle with TFIIH p52 Antibody (A-2) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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TFIIH p52 Antibody (A-2) is a mouse monoclonal IgA antibody that detects TFIIH p52 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). TFIIH p52 is a crucial component of the TFIIH complex, which plays a significant role in both transcription initiation and DNA repair processes. TFIIH p52 is primarily located in the nucleus, where TFIIH p52 participates in DNA unwinding during transcription and nucleotide excision repair, a vital mechanism for maintaining genomic integrity. TFIIH p52′s nuclear presence underscores its importance in cellular responses to DNA damage, as TFIIH p52 helps facilitate repair of lesions that could otherwise lead to mutations or cell death. Additionally, TFIIH p52 interacts with other subunits of the TFIIH complex, such as p44 and p62, which are essential for nucleotide excision repair, highlighting the collaborative nature of protein interactions in cellular processes. Anti-TFIIH p52 antibody (A-2) serves as an invaluable tool for researchers studying transcription regulation and DNA repair mechanisms, providing insights into the molecular underpinnings of these critical biological processes.
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TFIIH p52 Antibody (A-2) References:
- Cloning of the 62-kilodalton component of basic transcription factor BTF2. | Fischer, L., et al. 1992. Science. 257: 1392-5. PMID: 1529339
- Purification and interaction properties of the human RNA polymerase B(II) general transcription factor BTF2. | Gerard, M., et al. 1991. J Biol Chem. 266: 20940-5. PMID: 1939143
- Removal of 2-butoxyethanol gaseous emissions by biotrickling filtration packed with polyurethane foam. | Pérez, MC., et al. 2016. N Biotechnol. 33: 263-72. PMID: 26596886
- Systematic mutagenesis of TFIIH subunit p52/Tfb2 identifies residues required for XPB/Ssl2 subunit function and genetic interactions with TFB6. | Bassett, J., et al. 2022. J Biol Chem. 298: 102433. PMID: 36041630
- The DNA-dependent ATPase activity associated with the class II basic transcription factor BTF2/TFIIH. | Roy, R., et al. 1994. J Biol Chem. 269: 9826-32. PMID: 7511595
- Three unusual repair deficiencies associated with transcription factor BTF2(TFIIH): evidence for the existence of a transcription syndrome. | Vermeulen, W., et al. 1994. Cold Spring Harb Symp Quant Biol. 59: 317-29. PMID: 7587084
- Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2 (TFIIH). | van Vuuren, AJ., et al. 1994. EMBO J. 13: 1645-53. PMID: 8157004
- The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor. | Schaeffer, L., et al. 1994. EMBO J. 13: 2388-92. PMID: 8194528
- p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair. | Humbert, S., et al. 1994. EMBO J. 13: 2393-8. PMID: 8194529
- DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor. | Schaeffer, L., et al. 1993. Science. 260: 58-63. PMID: 8465201
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TFIIH p52 Antibody (A-2) | sc-271742 | 200 µg/ml | $322.00 | |||
TFIIH p52 Antibody (A-2): m-IgGκ BP-HRP Bundle | sc-552316 | 200 µg Ab; 40 µg BP | $361.00 | |||
TFIIH p52 (A-2) Neutralizing Peptide | sc-271742 P | 100 µg/0.5 ml | $69.00 | |||
TFIIH p52 Antibody (A-2) X | sc-271742 X | 200 µg/0.1 ml | $322.00 |